| 产品: | ALDH1A3 抗体 |
| 货号: | DF9187 |
| 描述: | Rabbit polyclonal antibody to ALDH1A3 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit |
| 分子量: | 56 kDa; 56kD(Calculated). |
| 蛋白号: | P47895 |
| RRID: | AB_2842383 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9187, RRID:AB_2842383.
展开/折叠
Acetaldehyde dehydrogenase 6; AL1A3_HUMAN; Aldehyde dehydrogenase 1A3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; Aldh1a3; ALDH1A6; ALDH6; RALDH 3; Retinaldehyde dehydrogenase 3; V1;
抗原和靶标
Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.
- P47895 AL1A3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGDKNP
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P47895 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K30 | Ubiquitination | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| K44 | Ubiquitination | Uniprot | |
| T56 | Phosphorylation | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| K154 | Ubiquitination | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| K263 | Ubiquitination | Uniprot | |
| K266 | Ubiquitination | Uniprot | |
| T278 | Phosphorylation | Uniprot | |
| Y327 | Phosphorylation | Uniprot | |
| S328 | Phosphorylation | Uniprot | |
| K340 | Ubiquitination | Uniprot | |
| K350 | Ubiquitination | Uniprot | |
| K360 | Ubiquitination | Uniprot | |
| K364 | Ubiquitination | Uniprot | |
| K373 | Ubiquitination | Uniprot | |
| K394 | Ubiquitination | Uniprot | |
| K409 | Ubiquitination | Uniprot | |
| K421 | Ubiquitination | Uniprot | |
| K423 | Ubiquitination | Uniprot | |
| S424 | Phosphorylation | Uniprot | |
| K430 | Ubiquitination | Uniprot | |
| Y437 | Phosphorylation | Uniprot | |
| T440 | Phosphorylation | Uniprot | |
| K446 | Ubiquitination | Uniprot | |
| Y492 | Phosphorylation | Uniprot | |
| Y497 | Phosphorylation | Uniprot | |
| T498 | Phosphorylation | Uniprot |
研究背景
NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid. Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde. Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region (By similarity).
Cytoplasm.
Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.
Homotetramer.
Belongs to the aldehyde dehydrogenase family.
研究领域
· Human Diseases > Cancers: Overview > Chemical carcinogenesis.
· Metabolism > Carbohydrate metabolism > Glycolysis / Gluconeogenesis.
· Metabolism > Amino acid metabolism > Histidine metabolism.
· Metabolism > Amino acid metabolism > Tyrosine metabolism.
· Metabolism > Amino acid metabolism > Phenylalanine metabolism.
· Metabolism > Metabolism of other amino acids > beta-Alanine metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.
· Metabolism > Global and overview maps > Metabolic pathways.
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