产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9196, RRID:AB_2842392.
展开/折叠
ALS 2; ALS2; ALS2_HUMAN; ALS2CR6; Alsin; ALSJ; Amyotrophic lateral sclerosis 2 (juvenile); Amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 6; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein; Amyotrophic lateral sclerosis 2 protein; Amyotrophic lateral sclerosis protein 2; FLJ31851; IAHSP; KIAA1563; MGC87187; PLSJ;
抗原和靶标
- Q96Q42 ALS2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLITMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQSVATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVREDSEHGEKPVPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKKVMNFYSTTPCETGAQAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPVLLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPLLSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLDSYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLPIRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFPGKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLWAEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSGSSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIKITGTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAWDNIAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDTPLHPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTIPLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDNDREEDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPTTKDACFASAVECLQQISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLGSEVHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q96Q42 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T31 | Phosphorylation | Uniprot | |
| K41 | Ubiquitination | Uniprot | |
| S353 | Phosphorylation | Uniprot | |
| S356 | Phosphorylation | Uniprot | |
| S361 | Phosphorylation | Uniprot | |
| S464 | Phosphorylation | Uniprot | |
| S465 | Phosphorylation | Uniprot | |
| S466 | Phosphorylation | Uniprot | |
| R481 | Methylation | Uniprot | |
| S483 | Phosphorylation | Uniprot | |
| S489 | Phosphorylation | Uniprot | |
| S492 | Phosphorylation | Uniprot | |
| T510 | Phosphorylation | Uniprot | |
| T526 | Phosphorylation | Uniprot | |
| T530 | Phosphorylation | Uniprot | |
| K533 | Acetylation | Uniprot | |
| K677 | Ubiquitination | Uniprot | |
| S714 | Phosphorylation | Uniprot | |
| K849 | Ubiquitination | Uniprot | |
| K993 | Ubiquitination | Uniprot | |
| Y1039 | Phosphorylation | Uniprot | |
| S1055 | Phosphorylation | Uniprot | |
| K1057 | Ubiquitination | Uniprot | |
| Y1084 | Phosphorylation | Uniprot | |
| K1160 | Ubiquitination | Uniprot | |
| K1281 | Acetylation | Uniprot | |
| K1292 | Acetylation | Uniprot | |
| S1335 | Phosphorylation | Uniprot | |
| S1342 | Phosphorylation | Uniprot | |
| T1344 | Phosphorylation | Uniprot | |
| S1349 | Phosphorylation | Uniprot | |
| Y1394 | Phosphorylation | Uniprot | |
| Y1398 | Phosphorylation | Uniprot | |
| S1452 | Phosphorylation | Uniprot | |
| S1458 | Phosphorylation | Uniprot | |
| S1460 | Phosphorylation | Uniprot | |
| S1462 | Phosphorylation | Uniprot | |
| S1464 | Phosphorylation | Uniprot | |
| Y1469 | Phosphorylation | Uniprot |
研究背景
May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity).
Forms a heteromeric complex with ALS2CL. Interacts with ALS2CL.
研究领域
· Human Diseases > Neurodegenerative diseases > Amyotrophic lateral sclerosis (ALS).
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