| 产品: | ARSB 抗体 |
| 货号: | DF9227 |
| 描述: | Rabbit polyclonal antibody to ARSB |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Dog, Chicken |
| 分子量: | 60 kDa; 60kD(Calculated). |
| 蛋白号: | P15848 |
| RRID: | AB_2842423 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9227, RRID:AB_2842423.
展开/折叠
Arsb; ARSB_HUMAN; Arylsulfatase B; ArylsulfataseB; ASB; G4S; MPS6; N acetylgalactosamine 4 sulfatase; N-acetylgalactosamine-4-sulfatase;
抗原和靶标
- P15848 ARSB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P15848 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T164 | Phosphorylation | Uniprot | |
| Y165 | Phosphorylation | Uniprot | |
| Y168 | Phosphorylation | Uniprot | |
| S177 | Phosphorylation | Uniprot | |
| T190 | Phosphorylation | Uniprot | |
| T204 | Phosphorylation | Uniprot | |
| S334 | Phosphorylation | Uniprot | |
| N366 | N-Glycosylation | Uniprot | |
| S417 | Phosphorylation | Uniprot | |
| Y491 | Phosphorylation | Uniprot |
研究背景
Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. This post-translational modification is severely defective in multiple sulfatase deficiency (MSD).
Lysosome. Cell surface.
Monomer.
Belongs to the sulfatase family.
研究领域
· Cellular Processes > Transport and catabolism > Lysosome. (View pathway)
· Metabolism > Glycan biosynthesis and metabolism > Glycosaminoglycan degradation.
· Metabolism > Global and overview maps > Metabolic pathways.
限制条款
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