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| 产品: | KCNJ8 抗体 |
| 货号: | DF9263 |
| 描述: | Rabbit polyclonal antibody to KCNJ8 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat, Rabbit |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 48 kDa; 48kD(Calculated). |
| 蛋白号: | Q15842 |
| RRID: | AB_2842459 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9263, RRID:AB_2842459.
展开/折叠
uKATP-1;KCNJ8; Kir6.1;uKATP 1;Potassium channel, inwardly rectifying subfamily J member 8;Inward rectifier K(+) channel Kir6.1;
抗原和靶标
- Q15842 KCNJ8_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLARKSIIPEEYVLARIAAENLRKPRIRDRLPKARFIAKSGACNLAHKNIREQGRFLQDIFTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLVAFAHGDIYAYMEKSGMEKSGLESTVCVTNVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLILQNIVGLIINAVMLGCIFMKTAQAHRRAETLIFSRHAVIAVRNGKLCFMFRVGDLRKSMIISASVRIQVVKKTTTPEGEVVPIHQLDIPVDNPIESNNIFLVAPLIICHVIDKRSPLYDISATDLANQDLEVIVILEGVVETTGITTQARTSYIAEEIQWGHRFVSIVTEEEGVYSVDYSKFGNTVKVAAPRCSARELDEKPSILIQTLQKSELSHQNSLRKRNSMRRNNSMRRNNSIRRNNSSLMVPKVQFMTPEGNQNTSES
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q15842 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S6 | Phosphorylation | Uniprot | |
| T62 | Phosphorylation | Uniprot | |
| S194 | Phosphorylation | Uniprot | |
| K217 | Acetylation | Uniprot | |
| T234 | Phosphorylation | Uniprot | |
| S275 | Phosphorylation | Uniprot | |
| Y278 | Phosphorylation | Uniprot | |
| S281 | Phosphorylation | Uniprot | |
| T283 | Phosphorylation | Uniprot | |
| S385 | Phosphorylation | Uniprot | |
| S397 | Phosphorylation | Uniprot | |
| S403 | Phosphorylation | Uniprot |
研究背景
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity).
Membrane>Multi-pass membrane protein.
Predominantly detected in fetal and adult heart.
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ8 subfamily.
研究领域
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
文献引用
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