| 产品: | BAAT 抗体 |
| 货号: | DF9277 |
| 描述: | Rabbit polyclonal antibody to BAAT |
| 应用: | WB IHC |
| 反应: | Human, Mouse |
| 预测: | Horse, Dog |
| 分子量: | 46 kDa; 46kD(Calculated). |
| 蛋白号: | Q14032 |
| RRID: | AB_2842473 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9277, RRID:AB_2842473.
展开/折叠
FLJ20300; BAAT; BAAT_HUMAN; BACAT; BAT; Bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase); Bile acid CoA:amino acid N acyltransferase; Bile acid Coenzyme A amino acid N acyltransferase glycine N choloyltransferase; Bile acid Coenzyme A: amino acid N acyltransferase; Bile acid-CoA:amino acid N-acyltransferase; Glycine N choloyltransferase; Glycine N-choloyltransferase; Long chain fatty acyl CoA hydrolase; Long-chain fatty-acyl-CoA hydrolase; MGC104432;
抗原和靶标
- Q14032 BAAT_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MIQLTATPVSALVDEPVHIRATGLIPFQMVSFQASLEDENGDMFYSQAHYRANEFGEVDLNHASSLGGDYMGVHPMGLFWSLKPEKLLTRLLKRDVMNRPFQVQVKLYDLELIVNNKVASAPKASLTLERWYVAPGVTRIKVREGRLRGALFLPPGEGLFPGVIDLFGGLGGLLEFRASLLASRGFASLALAYHNYEDLPRKPEVTDLEYFEEAANFLLRHPKVFGSGVGVVSVCQGVQIGLSMAIYLKQVTATVLINGTNFPFGIPQVYHGQIHQPLPHSAQLISTNALGLLELYRTFETTQVGASQYLFPIEEAQGQFLFIVGEGDKTINSKAHAEQAIGQLKRHGKNNWTLLSYPGAGHLIEPPYSPLCCASTTHDLRLHWGGEVIPHAAAQEHAWKEIQRFLRKHLIPDVTSQL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q14032 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y132 | Phosphorylation | Uniprot | |
| T138 | Phosphorylation | Uniprot | |
| Y196 | Phosphorylation | Uniprot | |
| Y210 | Phosphorylation | Uniprot | |
| S307 | Phosphorylation | Uniprot | |
| Y309 | Phosphorylation | Uniprot | |
| K334 | Acetylation | Uniprot | |
| K345 | Acetylation | Uniprot |
研究背景
Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine. More than 95% of the BAs are N-acyl amidates with glycine and taurine. Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism. This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption. May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.
Cytoplasm>Cytosol. Peroxisome.
Expressed in liver, gallbladder mucosa and pancreas.
Monomer.
Belongs to the C/M/P thioester hydrolase family.
研究领域
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
· Metabolism > Lipid metabolism > Primary bile acid biosynthesis.
· Metabolism > Metabolism of other amino acids > Taurine and hypotaurine metabolism.
· Metabolism > Lipid metabolism > Biosynthesis of unsaturated fatty acids.
· Metabolism > Global and overview maps > Metabolic pathways.
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