产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9339, RRID:AB_2842535.
展开/折叠
Carboxypeptidase D; CBPD_HUMAN; Cpd; gp180; Metallocarboxypeptidase D;
抗原和靶标
Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines.
- O75976 CBPD_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYHEEELESALREAAAAGLPGLARLFSIGRSVEGRPLWVLRLTAGLGSLIPEGDAGPDAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLPSLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTVTNVVVKEGPATEVDFSLRPTVTSVIPDTTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVHNTRIHLMPSMNPDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQPETIAVMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDDAVFQQIALSYSKENSQMFQGRPCKNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPLEKELPNFWEQNRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINHPVTTYKTGDYWRLLVPGTYKITASARGYNPVTKNVTVKSEGAIQVNFTLVRSSTDSNNESKKGKGASSSTNDASDPTTKEFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFLRGLVMNYPHITNLTNLGQSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNYKKNPAVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFTNNASQPETKAIIENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMGQPSCPNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAARLPSLWADNKRSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIKVQTKEGGYFHVLLAPGVHNIIAIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALILTACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O75976 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S27 | Phosphorylation | Uniprot | |
| T40 | O-Glycosylation | Uniprot | |
| T41 | O-Glycosylation | Uniprot | |
| T42 | O-Glycosylation | Uniprot | |
| T43 | O-Glycosylation | Uniprot | |
| T44 | O-Glycosylation | Uniprot | |
| S45 | O-Glycosylation | Uniprot | |
| N172 | N-Glycosylation | Uniprot | |
| S203 | Phosphorylation | Uniprot | |
| K281 | Ubiquitination | Uniprot | |
| T282 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | Uniprot | |
| K289 | Ubiquitination | Uniprot | |
| K293 | Ubiquitination | Uniprot | |
| Y356 | Phosphorylation | Uniprot | |
| T489 | O-Glycosylation | Uniprot | |
| Y520 | Phosphorylation | Uniprot | |
| Y527 | Phosphorylation | Uniprot | |
| K531 | Ubiquitination | Uniprot | |
| S532 | Phosphorylation | Uniprot | |
| T587 | Phosphorylation | Uniprot | |
| Y611 | Phosphorylation | Uniprot | |
| N811 | N-Glycosylation | Uniprot | |
| S895 | Phosphorylation | Uniprot | |
| T898 | Phosphorylation | Uniprot | |
| T899 | Phosphorylation | Uniprot | |
| K900 | Ubiquitination | Uniprot | |
| T904 | Phosphorylation | Uniprot | |
| S910 | Phosphorylation | Uniprot | |
| N955 | N-Glycosylation | Uniprot | |
| R1027 | Methylation | Uniprot | |
| S1035 | Phosphorylation | Uniprot | |
| T1050 | Phosphorylation | Uniprot | |
| S1051 | Phosphorylation | Uniprot | |
| T1056 | Phosphorylation | Uniprot | |
| N1070 | N-Glycosylation | Uniprot | |
| K1220 | Ubiquitination | Uniprot | |
| S1324 | Phosphorylation | Uniprot | |
| K1331 | Ubiquitination | Uniprot | |
| Y1344 | Phosphorylation | Uniprot | |
| S1352 | Phosphorylation | Uniprot | |
| S1355 | Phosphorylation | Uniprot | |
| K1357 | Ubiquitination | Uniprot | |
| S1358 | Phosphorylation | Uniprot | |
| S1361 | Phosphorylation | Uniprot | |
| T1368 | Phosphorylation | Uniprot | |
| T1370 | Phosphorylation | Uniprot | |
| T1374 | Phosphorylation | Uniprot | |
| Y1376 | Phosphorylation | Uniprot | |
| S1377 | Phosphorylation | Uniprot | |
| S1378 | Phosphorylation | Uniprot | |
| K1379 | Ubiquitination | Uniprot |
研究背景
Cell membrane>Single-pass type I membrane protein.
Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines.
There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity.
Belongs to the peptidase M14 family.
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