产品: CEACAM7 抗体
货号: DF9346
描述: Rabbit polyclonal antibody to CEACAM7
应用: WB IF/ICC
反应: Human
分子量: 29kDa; 29kD(Calculated).
蛋白号: Q14002
RRID: AB_2842542

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产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
克隆:
Polyclonal
特异性:
CEACAM7 Antibody detects endogenous levels of total CEACAM7.
RRID:
AB_2842542
引用格式: Affinity Biosciences Cat# DF9346, RRID:AB_2842542.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Carcinoembryonic antigen CGM 2; Carcinoembryonic antigen CGM2; Carcinoembryonic antigen gene family member 2; Carcinoembryonic antigen related cell adhesion molecule 7; Carcinoembryonic antigen-related cell adhesion molecule 7; CEA; CEACAM 7; CEACAM7; CEAM7_HUMAN; CGM 2; CGM2;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
Q14002 CEAM7_HUMAN:

Expressed in columnar epithelial cells of the colon (at protein level) (PubMed:10436421). Strongly down-regulated in colonic adenocarcinomas.

序列:
MGSPSACPYRVCIPWQGLLLTASLLTFWNLPNSAQTNIDVVPFNVAEGKEVLLVVHNESQNLYGYNWYKGERVHANYRIIGYVKNISQENAPGPAHNGRETIYPNGTLLIQNVTHNDAGFYTLHVIKENLVNEEVTRQFYVFSEPPKPSITSNNFNPVENKDIVVLTCQPETQNTTYLWWVNNQSLLVSPRLLLSTDNRTLVLLSATKNDIGPYECEIQNPVGASRSDPVTLNVRYESVQASSPDLSAGTAVSIMIGVLAGMALI

翻译修饰 - Q14002 作为底物

Site PTM Type Enzyme
Y236 Phosphorylation
S242 Phosphorylation
S243 Phosphorylation
T250 Phosphorylation

研究背景

细胞定位:

Cell membrane>Lipid-anchor. Apical cell membrane.
Note: Localized to the apical glycocalyx surface.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed in columnar epithelial cells of the colon (at protein level). Strongly down-regulated in colonic adenocarcinomas.

亚基结构:

Homodimer.

蛋白家族:

Belongs to the immunoglobulin superfamily. CEA family.

文献引用

1). RNA-sequencing expression profile and functional analysis of retinal pigment epithelium in atrophic age-related macular degeneration. Journal of biomedical research, 2024 (PubMed: 38808557) [IF=2.3]

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