CTNND2 Antibody - #DF9348

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产品: CTNND2 抗体
货号: DF9348
描述: Rabbit polyclonal antibody to CTNND2
应用: WB
反应: Human, Mouse
预测: Pig, Bovine, Sheep, Rabbit, Dog, Chicken
分子量: 133 kDa; 133kD(Calculated).
蛋白号: Q9UQB3
RRID: AB_2842544

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Pig(100%), Bovine(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%)
克隆:
Polyclonal
特异性:
CTNND2 Antibody detects endogenous levels of total CTNND2.
RRID:
AB_2842544
引用格式: Affinity Biosciences Cat# DF9348, RRID:AB_2842544.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

ARM-repeat protein; Catenin (cadherin associated protein) delta 2; catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein); Catenin delta 2; Catenin delta-2; CTND2_HUMAN; CTNND 2; Ctnnd2; Delta catenin; Delta-catenin; GT 24; GT24; Neural plakophilin related arm repeat protein; Neural plakophilin related armadillo repeat protein; Neural plakophilin-related ARM-repeat protein; Neural plakophilin-related, Neurojungin; Neurojungin; NPRAP; T cell delta catenin;

抗原和靶标

免疫原:
Uniprot:

Q9UQB3(CTND2_HUMAN) >>Visit HPA database.

基因/基因ID:
CTNND2(1501)
表达:
Q9UQB3 CTND2_HUMAN:

Expressed in brain; highest expression is observed in fetal brain (PubMed:25807484).

序列:
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQELQFERLTRELEAERQIVASQLERCKLGSETGSMSSMSSAEEQFQWQSQDGQKDIEDELTTGLELVDSCIRSLQESGILDPQDYSTGERPSLLSQSALQLNSKPEGSFQYPASYHSNQTLALGETTPSQLPARGTQARATGQSFSQGTTSRAGHLAGPEPAPPPPPPPREPFAPSLGSAFHLPDAPPAAAAAALYYSSSTLPAPPRGGSPLAAPQGGSPTKLQRGGSAPEGATYAAPRGSSPKQSPSRLAKSYSTSSPINIVVSSAGLSPIRVTSPPTVQSTISSSPIHQLSSTIGTYATLSPTKRLVHASEQYSKHSQELYATATLQRPGSLAAGSRASYSSQHGHLGPELRALQSPEHHIDPIYEDRVYQKPPMRSLSQSQGDPLPPAHTGTYRTSTAPSSPGVDSVPLQRTGSQHGPQNAAAATFQRASYAAGPASNYADPYRQLQYCPSVESPYSKSGPALPPEGTLARSPSIDSIQKDPREFGWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQHMGTDELDGLLCGEANGKDAESSGCWGKKKKKKKSQDQWDGVGPLPDCAEPPKGIQMLWHPSIVKPYLTLLSECSNPDTLEGAAGALQNLAAGSWKWSVYIRAAVRKEKGLPILVELLRIDNDRVVCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGGNNSNNTASKAMSDDTVTAVCCTLHEVITKNMENAKALRDAGGIEKLVGISKSKGDKHSPKVVKAASQVLNSMWQYRDLRSLYKKDGWSQYHFVASSSTIERDRQRPYSSSRTPSISPVRVSPNNRSASAPASPREMISLKERKTDYECTGSNATYHGAKGEHTSRKDAMTAQNTGISTLYRNSYGAPAEDIKHNQVSAQPVPQEPSRKDYETYQPFQNSTRNYDESFFEDQVHHRPPASEYTMHLGLKSTGNYVDFYSAARPYSELNYETSHYPASPDSWV

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Chicken
100
Rabbit
100
Horse
0
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q9UQB3 作为底物

Site PTM Type Enzyme
S43 Phosphorylation
S201 Phosphorylation
S267 Phosphorylation
S276 Phosphorylation
S285 Phosphorylation
Y292 Phosphorylation
S298 Phosphorylation
S303 Phosphorylation
S305 Phosphorylation
Y372 Phosphorylation
Y380 Phosphorylation
Y399 Phosphorylation
S415 Phosphorylation
Y424 Phosphorylation
Y429 Phosphorylation
T457 Phosphorylation P31749 (AKT1)
S461 Phosphorylation
S474 Phosphorylation
S490 Phosphorylation
S497 Phosphorylation
Y499 Phosphorylation
Y503 Phosphorylation
Y508 Phosphorylation
S511 Phosphorylation
S514 Phosphorylation
Y516 Phosphorylation
S517 Phosphorylation
S532 Phosphorylation
S534 Phosphorylation
S537 Phosphorylation
K540 Ubiquitination
K926 Ubiquitination
K931 Ubiquitination
Y932 Phosphorylation
S1002 Phosphorylation
T1042 Phosphorylation
T1056 Phosphorylation P49841 (GSK3B)
S1060 Phosphorylation
S1065 Phosphorylation
S1072 Phosphorylation
Y1090 Phosphorylation
Y1099 Phosphorylation
T1122 Phosphorylation
S1127 Phosphorylation
Y1154 Phosphorylation
Y1157 Phosphorylation
S1193 Phosphorylation
Y1197 Phosphorylation
Y1201 Phosphorylation
Y1207 Phosphorylation
Y1217 Phosphorylation

研究背景

功能:

Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signaling. It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.

翻译修饰:

O-glycosylated.

Phosphorylated by CDK5 (By similarity). Phosphorylated by GSK3B.

细胞定位:

Nucleus. Cell junction>Adherens junction. Cell projection>Dendrite. Perikaryon.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed in brain; highest expression is observed in fetal brain.

亚基结构:

Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain (By similarity). Interacts with PDZD2 (By similarity). Interacts with ZBTB33 (By similarity). Binds to PSEN1. Interacts with ARHGEF28. Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain). Interacts with CDK5 (By similarity). Interacts with CTNNB1. Interacts with GSK3A and GSK3B. Interacts with DNM2. Interacts with CCDC85B.

蛋白家族:

Belongs to the beta-catenin family.

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