NTHL1 Antibody - #DF9498
| 产品: | NTHL1 抗体 |
| 货号: | DF9498 |
| 描述: | Rabbit polyclonal antibody to NTHL1 |
| 应用: | WB |
| 反应: | Human, Mouse, Monkey |
| 预测: | Pig, Zebrafish, Bovine, Horse, Chicken, Xenopus |
| 分子量: | 34 kDa; 34kD(Calculated). |
| 蛋白号: | P78549 |
| RRID: | AB_2842694 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9498, RRID:AB_2842694.
展开/折叠
Bifunctional DNA N glycoslyase/DNA (apurinic or apyrimidinic site) lyase; DNA glycoslyase/AP lyase; Endonuclease III like protein 1; Endonuclease III-like protein 1; hNTH1; NTH 1; nth endonuclease III like 1 (E. coli); NTH endonuclease III Like 1; NTH1; NTHL 1; Nthl1; NTHL1_HUMAN; OCTS 3; OCTS3;
抗原和靶标
- P78549 NTH_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MCSPQESGMTALSARMLTRSRSLGPGAGPRGCREEPGPLRRREAAAEARKSHSPVKRPRKAQRLRVAYEGSDSEKGEGAEPLKVPVWEPQDWQQQLVNIRAMRNKKDAPVDHLGTEHCYDSSAPPKVRRYQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVAELVALPGVGPKMAHLAMAVAWGTVSGIAVDTHVHRIANRLRWTKKATKSPEETRAALEEWLPRELWHEINGLLVGFGQQTCLPVHPRCHACLNQALCPAAQGL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P78549 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S3 | Phosphorylation | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| R21 | Methylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| S53 | Phosphorylation | Uniprot | |
| Y68 | Phosphorylation | Uniprot | |
| S71 | Phosphorylation | Uniprot | |
| S73 | Phosphorylation | Uniprot | |
| K83 | Ubiquitination | Uniprot | |
| K106 | Ubiquitination | Uniprot | |
| S135 | Phosphorylation | Uniprot | |
| S140 | Phosphorylation | Uniprot | |
| T147 | Phosphorylation | Uniprot | |
| T160 | Phosphorylation | Uniprot | |
| S163 | Phosphorylation | Uniprot | |
| T171 | Phosphorylation | Uniprot | |
| K174 | Ubiquitination | Uniprot | |
| Y177 | Phosphorylation | Uniprot |
研究背景
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
Nucleus. Mitochondrion.
Widely expressed with highest levels in heart and lowest levels in lung and liver.
Interacts with YBX1.
Belongs to the Nth/MutY family.
研究领域
· Genetic Information Processing > Replication and repair > Base excision repair.
限制条款
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