| 产品: | EDC4 抗体 |
| 货号: | DF9501 |
| 描述: | Rabbit polyclonal antibody to EDC4 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 152 kDa; 152kD(Calculated). |
| 蛋白号: | Q6P2E9 |
| RRID: | AB_2842697 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9501, RRID:AB_2842697.
展开/折叠
autoantigen; Autoantigen Ge 1; Autoantigen Ge-1; Autoantigen Ge1; Autoantigen RCD 8; Autoantigen RCD-8; Autoantigen RCD8; edc4; EDC4_HUMAN; Enhancer of mRNA decapping 4; Enhancer of mRNA-decapping protein 4; Ge 1; Hedls; Human enhancer of decapping large subunit; RCD 8;
抗原和靶标
- Q6P2E9 EDC4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASCASIDIEDATQHLRDILKLDRPAGGPSAESPRPSSAYNGDLNGLLVPDPLCSGDSTSANKTGLRTMPPINLQEKQVICLSGDDSSTCIGILAKEVEIVASSDSSISSKARGSNKVKIQPVAKYDWEQKYYYGNLIAVSNSFLAYAIRAANNGSAMVRVISVSTSERTLLKGFTGSVADLAFAHLNSPQLACLDEAGNLFVWRLALVNGKIQEEILVHIRQPEGTPLNHFRRIIWCPFIPEESEDCCEESSPTVALLHEDRAEVWDLDMLRSSHSTWPVDVSQIKQGFIVVKGHSTCLSEGALSPDGTVLATASHDGYVKFWQIYIEGQDEPRCLHEWKPHDGRPLSCLLFCDNHKKQDPDVPFWRFLITGADQNRELKMWCTVSWTCLQTIRFSPDIFSSVSVPPSLKVCLDLSAEYLILSDVQRKVLYVMELLQNQEEGHACFSSISEFLLTHPVLSFGIQVVSRCRLRHTEVLPAEEENDSLGADGTHGAGAMESAAGVLIKLFCVHTKALQDVQIRFQPQLNPDVVAPLPTHTAHEDFTFGESRPELGSEGLGSAAHGSQPDLRRIVELPAPADFLSLSSETKPKLMTPDAFMTPSASLQQITASPSSSSSGSSSSSSSSSSSLTAVSAMSSTSAVDPSLTRPPEELTLSPKLQLDGSLTMSSSGSLQASPRGLLPGLLPAPADKLTPKGPGQVPTATSALSLELQEVEPLGLPQASPSRTRSPDVISSASTALSQDIPEIASEALSRGFGSSAPEGLEPDSMASAASALHLLSPRPRPGPELGPQLGLDGGPGDGDRHNTPSLLEAALTQEASTPDSQVWPTAPDITRETCSTLAESPRNGLQEKHKSLAFHRPPYHLLQQRDSQDASAEQSDHDDEVASLASASGGFGTKVPAPRLPAKDWKTKGSPRTSPKLKRKSKKDDGDAAMGSRLTEHQVAEPPEDWPALIWQQQRELAELRHSQEELLQRLCTQLEGLQSTVTGHVERALETRHEQEQRRLERALAEGQQRGGQLQEQLTQQLSQALSSAVAGRLERSIRDEIKKTVPPCVSRSLEPMAGQLSNSVATKLTAVEGSMKENISKLLKSKNLTDAIARAAADTLQGPMQAAYREAFQSVVLPAFEKSCQAMFQQINDSFRLGTQEYLQQLESHMKSRKAREQEAREPVLAQLRGLVSTLQSATEQMAATVAGSVRAEVQHQLHVAVGSLQESILAQVQRIVKGEVSVALKEQQAAVTSSIMQAMRSAAGTPVPSAHLDCQAQQAHILQLLQQGHLNQAFQQALTAADLNLVLYVCETVDPAQVFGQPPCPLSQPVLLSLIQQLASDLGTRTDLKLSYLEEAVMHLDHSDPITRDHMGSVMAQVRQKLFQFLQAEPHNSLGKAARRLSLMLHGLVTPSLP
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q6P2E9 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S3 | Phosphorylation | Uniprot | |
| S6 | Phosphorylation | Uniprot | |
| K21 | Ubiquitination | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| S33 | Phosphorylation | Uniprot | |
| S37 | Phosphorylation | Uniprot | |
| K63 | Ubiquitination | Uniprot | |
| S104 | Phosphorylation | Uniprot | |
| S106 | Phosphorylation | Uniprot | |
| S107 | Phosphorylation | Uniprot | |
| S110 | Phosphorylation | Uniprot | |
| K111 | Ubiquitination | Uniprot | |
| K119 | Ubiquitination | Uniprot | |
| K125 | Acetylation | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| S486 | Phosphorylation | Uniprot | |
| S555 | Phosphorylation | Uniprot | |
| S560 | Phosphorylation | Uniprot | |
| S565 | Phosphorylation | Uniprot | |
| S583 | Phosphorylation | Uniprot | |
| S585 | Phosphorylation | Uniprot | |
| S586 | Phosphorylation | Uniprot | |
| T588 | Phosphorylation | Uniprot | |
| S613 | Phosphorylation | Uniprot | |
| S621 | Phosphorylation | Uniprot | |
| S622 | Phosphorylation | Uniprot | |
| S623 | Phosphorylation | Uniprot | |
| S624 | Phosphorylation | Uniprot | |
| S664 | Phosphorylation | Uniprot | |
| S676 | Phosphorylation | Uniprot | |
| T693 | Phosphorylation | Uniprot | |
| S708 | Phosphorylation | Uniprot | |
| S723 | Phosphorylation | Uniprot | |
| S725 | Phosphorylation | Uniprot | |
| T727 | Phosphorylation | Uniprot | |
| S729 | Phosphorylation | Uniprot | |
| S734 | Phosphorylation | Uniprot | |
| S735 | Phosphorylation | Uniprot | |
| S737 | Phosphorylation | Uniprot | |
| T738 | Phosphorylation | Uniprot | |
| S741 | Phosphorylation | Uniprot | |
| S780 | Phosphorylation | Uniprot | |
| T807 | Phosphorylation | Uniprot | |
| S809 | Phosphorylation | Uniprot | |
| S820 | Phosphorylation | Uniprot | |
| T821 | Phosphorylation | Uniprot | |
| S824 | Phosphorylation | Uniprot | |
| T837 | Phosphorylation | Uniprot | |
| S844 | Phosphorylation | Uniprot | |
| S855 | Phosphorylation | Uniprot | |
| Y863 | Phosphorylation | Uniprot | |
| S871 | Phosphorylation | Uniprot | |
| S875 | Phosphorylation | Uniprot | |
| S879 | Phosphorylation | Uniprot | |
| S887 | Phosphorylation | Uniprot | |
| S892 | Phosphorylation | Uniprot | |
| T911 | Phosphorylation | Uniprot | |
| S914 | Phosphorylation | Uniprot | |
| S918 | Phosphorylation | Uniprot | |
| R965 | Methylation | Uniprot | |
| S967 | Phosphorylation | Uniprot | |
| R1015 | Methylation | Uniprot | |
| T1050 | Phosphorylation | Uniprot | |
| C1054 | S-Nitrosylation | Uniprot | |
| S1058 | Phosphorylation | Uniprot | |
| S1067 | Phosphorylation | Uniprot | |
| T1072 | Phosphorylation | Uniprot | |
| T1075 | Phosphorylation | Uniprot | |
| S1080 | Phosphorylation | Uniprot | |
| K1082 | Ubiquitination | Uniprot | |
| K1087 | Ubiquitination | Uniprot | |
| K1092 | Ubiquitination | Uniprot | |
| Y1148 | Phosphorylation | Uniprot | |
| S1154 | Phosphorylation | Uniprot | |
| K1157 | Ubiquitination | Uniprot | |
| K1368 | Ubiquitination | Uniprot | |
| S1380 | Phosphorylation | Uniprot | |
| K1383 | Ubiquitination | Uniprot | |
| S1389 | Phosphorylation | Uniprot | |
| S1399 | Phosphorylation | Uniprot |
研究背景
In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro).
Cytoplasm>P-body. Nucleus.
Part of a decapping complex consisting of DCP1A, DCP2, EDC3, EDC4 and probably DDX6. Part of a complex consisting of DCP1A, EDC3, EDC4 and DDX6. Part of a complex consisting of DCP1B, EDC3, EDC4 and DDX6. Interacts with DCP2. Interacts with RC3H1 (By similarity). Interacts with NBDY. Interacts with TEX19 (By similarity).
Belongs to the WD repeat EDC4 family.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > RNA degradation.
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