| 产品: | GABRE 抗体 |
| 货号: | DF9524 |
| 描述: | Rabbit polyclonal antibody to GABRE |
| 应用: | WB |
| 反应: | Human |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 58 kDa; 58kD(Calculated). |
| 蛋白号: | P78334 |
| RRID: | AB_2842720 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9524, RRID:AB_2842720.
展开/折叠
GABA(A) receptor epsilon; GABA(A) receptor subunit epsilon; Gabre; Gamma aminobutyric acid (GABA) A receptor epsilon; Gamma aminobutyric acid receptor subunit epsilon; Gamma-aminobutyric acid receptor subunit epsilon; GBRE_HUMAN;
抗原和靶标
Expressed in many tissues. Highest levels of expression in adult heart and placenta.
- P78334 GBRE_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLSKVLPVLLGILLILQSRVEGPQTESKNEASSRDVVYGPQPQPLENQLLSEETKSTETETGSRVGKLPEASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSWKLFQFDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEERPSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRLDNYSRVVFPVTFFFFNVLYWLVCLNL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P78334 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T163 | Phosphorylation | Uniprot | |
| Y178 | Phosphorylation | Uniprot | |
| S196 | Phosphorylation | Uniprot |
研究背景
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Cell junction>Synapse>Postsynaptic cell membrane>Multi-pass membrane protein. Cell membrane>Multi-pass membrane protein.
Expressed in many tissues. Highest levels of expression in adult heart and placenta.
Generally pentameric. Associates with alpha and beta subunits.
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRE sub-subfamily.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Human Diseases > Substance dependence > Morphine addiction.
· Organismal Systems > Nervous system > Retrograde endocannabinoid signaling. (View pathway)
· Organismal Systems > Nervous system > GABAergic synapse.
限制条款
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