| 产品: | GCFC1 抗体 |
| 货号: | DF9529 |
| 描述: | Rabbit polyclonal antibody to GCFC1 |
| 应用: | WB |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 105 kDa; 105kD(Calculated). |
| 蛋白号: | Q9Y5B6 |
| RRID: | AB_2842725 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9529, RRID:AB_2842725.
展开/折叠
BM 020; BM020; Chromosome 21 open reading frame 66; FSAP105; Functional spliceosome-associated protein 105; GC rich sequence DNA binding factor candidate; GC-rich sequence DNA-binding factor 1; GCFC; GCFC1; GCFC1_HUMAN; PAX3 and PAX7 binding protein 1; PAXBP1;
抗原和靶标
- Q9Y5B6 PAXB1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MFRKARRVNVRKRNDSEEEERERDEEQEPPPLLPPPGTGEEAGPGGGDRAPGGESLLGPGPSPPSALTPGLGAEAGGGFPGGAEPGNGLKPRKRPRENKEVPRASLLSFQDEEEENEEVFKVKKSSYSKKIVKLLKKEYKEDLEKSKIKTELNSSAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMESEKEEEKPKTGGAFSNALSSLNVLRPGEIPDAAFIHAARKKRQMARELGDFTPHDNEPGKGRLVREDENDASDDEDDDEKRRIVFSVKEKSQRQKIAEEIGIEGSDDDALVTGEQDEELSRWEQEQIRKGINIPQVQASQPAEVNMYYQNTYQTMPYGSSYGIPYSYTAYGSSDAKSQKTDNTVPFKTPSNEMTPVTIDLVKKQLKDRLDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHSNKALMAPNLDSFGRDRALYQEHAKRRIAEREARRTRRRQAREQTGKMADHLEGLSSDDEETSTDITNFNLEKDRISKESGKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLEAKCRDFENMLWFESLLFYGCEEREQEKDDVDVALLPTIVEKVILPKLTVIAENMWDPFSTTQTSRMVGITLKLINGYPSVVNAENKNTQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFFQRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLLASVRALDHAMSVASDHNVKEFKSLIEGK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9Y5B6 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S16 | Phosphorylation | Uniprot | |
| S62 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| K121 | Methylation | Uniprot | |
| K123 | Methylation | Uniprot | |
| K149 | Sumoylation | Uniprot | |
| T150 | Phosphorylation | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| S155 | Phosphorylation | Uniprot | |
| S158 | Phosphorylation | Uniprot | |
| K164 | Acetylation | Uniprot | |
| S180 | Phosphorylation | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| K193 | Acetylation | Uniprot | |
| K197 | Sumoylation | Uniprot | |
| T242 | Phosphorylation | Uniprot | |
| S262 | Phosphorylation | Uniprot | |
| K278 | Acetylation | Uniprot | |
| S295 | Phosphorylation | Uniprot | |
| T378 | Phosphorylation | Uniprot | |
| K442 | Ubiquitination | Uniprot | |
| Y476 | Phosphorylation | Uniprot | |
| K492 | Sumoylation | Uniprot | |
| Y521 | Phosphorylation | Uniprot | |
| S557 | Phosphorylation | Uniprot | |
| S558 | Phosphorylation | Uniprot | |
| T563 | Phosphorylation | Uniprot | |
| K624 | Ubiquitination | Uniprot | |
| K682 | Ubiquitination | Uniprot | |
| Y718 | Phosphorylation | Uniprot | |
| S720 | Phosphorylation | Uniprot | |
| T729 | Phosphorylation | Uniprot | |
| Y855 | Phosphorylation | Uniprot |
研究背景
Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity).
Nucleus.
Ubiquitous.
Interacts with PAX3 and PAX7. Interacts with WDR5; associates with a histone methyltransferase (HMT) complex composed at least of RBBP5, ASH2L, SET1, SET2 and KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4 through direct interaction with WDR5 (By similarity).
Belongs to the GCF family.
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