GPHN Antibody - #DF9531

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产品: GPHN 抗体
货号: DF9531
描述: Rabbit polyclonal antibody to GPHN
应用: WB IHC
反应: Human, Mouse
预测: Pig, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 80 kDa; 80kD(Calculated).
蛋白号: Q9NQX3
RRID: AB_2842727

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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WB Handbook
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产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Pig(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)
克隆:
Polyclonal
特异性:
GPHN Antibody detects endogenous levels of total GPHN.
RRID:
AB_2842727
引用格式: Affinity Biosciences Cat# DF9531, RRID:AB_2842727.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Domain E; Domain G; GEPH; GEPH_HUMAN; GPH; GPHN; GPHRYN; KIAA1385; Molybdopterin molybdenumtransferase; MPT adenylyltransferase; MPT Mo-transferase;

抗原和靶标

免疫原:
Uniprot:

Q9NQX3(GEPH_HUMAN) >>Visit HPA database.

基因/基因ID:
GPHN(10243)
序列:
MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETLIDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTLIINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGVQCEEEEEEKKDSGVASTEDSSSSHITAAAIAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLSTASCPTPKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Sheep
100
Dog
100
Xenopus
100
Chicken
100
Rabbit
100
Bovine
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q9NQX3 作为底物

Site PTM Type Enzyme
R34 Methylation
T52 Phosphorylation
S54 Phosphorylation
K57 Ubiquitination
T96 Phosphorylation
T100 Phosphorylation
T139 Phosphorylation
S147 Phosphorylation
S188 Phosphorylation
S194 Phosphorylation
T198 Phosphorylation
T199 Phosphorylation
S200 Phosphorylation
S230 Phosphorylation
S250 Phosphorylation
T265 Phosphorylation
T266 Phosphorylation
S268 Phosphorylation
S270 Phosphorylation P06493 (CDK1) , Q00535 (CDK5) , P49841 (GSK3B)
T276 Phosphorylation
S277 Phosphorylation
S280 Phosphorylation
T281 Phosphorylation
S283 Phosphorylation
T286 Phosphorylation
S291 Phosphorylation
S294 Phosphorylation
S295 Phosphorylation
K296 Ubiquitination
S303 Phosphorylation
S305 Phosphorylation
S319 Phosphorylation
S371 Phosphorylation
S393 Phosphorylation
T402 Phosphorylation
S480 Phosphorylation
T570 Phosphorylation
S571 Phosphorylation
S575 Phosphorylation
T655 Phosphorylation

研究背景

功能:

Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.

细胞定位:

Cell junction>Synapse. Cell junction>Synapse>Postsynaptic cell membrane>Peripheral membrane protein>Cytoplasmic side. Cytoplasm>Cytoskeleton. Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cell projection>Dendrite. Cell junction>Synapse>Postsynaptic density.
Note: Cytoplasmic face of glycinergic postsynaptic membranes.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Homotrimer, homodimer and homooligomer. Interacts with GABARAP (By similarity). Interacts with SRGAP2 (via SH3 domain) (By similarity). Interacts with GABRA3. Interacts with GLRB. GABRA3 and GLRB occupy overlapping binding sites (By similarity). Interacts with ARHGAP32; IQSEC3, INSYN1 and INSYN2A (By similarity).

蛋白家族:

In the N-terminal section; belongs to the MoaB/Mog family.

In the C-terminal section; belongs to the MoeA family.

研究领域

· Metabolism > Metabolism of cofactors and vitamins > Folate biosynthesis.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Nervous system > GABAergic synapse.

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