| 产品: | GPSM1 抗体 |
| 货号: | DF9539 |
| 描述: | Rabbit polyclonal antibody to GPSM1 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Sheep |
| 分子量: | 75 kDa; 75kD(Calculated). |
| 蛋白号: | Q86YR5 |
| RRID: | AB_2842735 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9539, RRID:AB_2842735.
展开/折叠
Activator of G-protein signaling 3; AGS3; AGS3 homolog; C10a; G protein signaling modulator 1 (AGS3 like, C. elegans); G-protein-signaling modulator 1; GPSM1; GPSM1_HUMAN;
抗原和靶标
- Q86YR5 GPSM1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLEREQNGDSHHSGDWRGPSRDSLPLPVRSRKYQEGPDAERRPREGSHSPLDSADVRVHVPRTSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQPSMTASPQTEEFFDLIASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFFNMLIKYQSSRIDDQRCPPPDVLPRGPTMPDEDFFSLIQRVQAKRMDEQRVDLAGGPEQGAGGPPEPQQQCQPGAS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q86YR5 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K40 | Ubiquitination | Uniprot | |
| K45 | Ubiquitination | Uniprot | |
| K90 | Ubiquitination | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| K117 | Ubiquitination | Uniprot | |
| S134 | Phosphorylation | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| Y150 | Phosphorylation | Uniprot | |
| Y156 | Phosphorylation | Uniprot | |
| K161 | Ubiquitination | Uniprot | |
| K187 | Ubiquitination | Uniprot | |
| K200 | Ubiquitination | Uniprot | |
| K233 | Ubiquitination | Uniprot | |
| K240 | Ubiquitination | Uniprot | |
| K245 | Ubiquitination | Uniprot | |
| Y252 | Phosphorylation | Uniprot | |
| K274 | Ubiquitination | Uniprot | |
| Y311 | Phosphorylation | Uniprot | |
| R325 | Methylation | Uniprot | |
| K354 | Ubiquitination | Uniprot | |
| S387 | Phosphorylation | Uniprot | |
| K393 | Ubiquitination | Uniprot | |
| S413 | Phosphorylation | Uniprot | |
| R421 | Methylation | Uniprot | |
| S445 | Phosphorylation | Uniprot | |
| S469 | Phosphorylation | Uniprot | |
| S471 | Phosphorylation | Uniprot | |
| R479 | Methylation | Uniprot | |
| S486 | Phosphorylation | Uniprot | |
| S492 | Phosphorylation | Uniprot | |
| S493 | Phosphorylation | Uniprot | |
| K504 | Ubiquitination | Uniprot | |
| C515 | S-Nitrosylation | Uniprot | |
| S541 | Phosphorylation | Uniprot | |
| S545 | Phosphorylation | Uniprot | |
| T548 | Phosphorylation | Uniprot | |
| S569 | Phosphorylation | Uniprot | |
| S572 | Phosphorylation | Uniprot | |
| C670 | S-Nitrosylation | Uniprot |
研究背景
Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.
Phosphorylation regulates interaction with G(i/o) alpha.
Cytoplasm>Cytosol. Endoplasmic reticulum membrane>Peripheral membrane protein>Cytoplasmic side. Golgi apparatus membrane>Peripheral membrane protein>Cytoplasmic side. Cell membrane>Peripheral membrane protein>Cytoplasmic side.
Expressed in intestinal cells.
Interacts with GNAI1, GNAI2 and GNAI3 preferentially in their GDP-bound state. May also interact with GNAO1. Interacts with STK11/LKB1 and MACF1 (By similarity). Interacts with INSC/inscuteable and FRMPD1.
The GoLoco domains mediate interaction with G(i/o) alpha (By similarity). The GoLoco domains are essential for the GDI activity toward G(i/o) alpha.
Belongs to the GPSM family.
研究领域
· Human Diseases > Substance dependence > Cocaine addiction.
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