产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9554, RRID:AB_2842750.
展开/折叠
COPII associated small GTPase; COPII-associated small GTPase; GTP binding protein SAR1a; GTP-binding protein SAR1a; Masra 2; Masra2; SAR 1; SAR1 gene homolog A; SAR1 homolog A (S. cerevisiae); SAR1A; SAR1a gene homolog (S cerevisiae) 1; SAR1a gene homolog 1 (S cerevisiae); SAR1a gene homolog 1; SAR1A_HUMAN; SARA 1; Sara; SARA1;
抗原和靶标
- Q9NR31 SAR1A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSFIFEWIYNGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHEQARRVWKNYLPAINGIVFLVDCADHSRLVESKVELNALMTDETISNVPILILGNKIDRTDAISEEKLREIFGLYGQTTGKGNVTLKELNARPMEVFMCSVLKRQGYGEGFRWLSQYID
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9NR31 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K27 | Ubiquitination | Uniprot | |
| T39 | Phosphorylation | Uniprot | |
| T40 | Phosphorylation | Uniprot | |
| K46 | Ubiquitination | Uniprot | |
| T60 | Phosphorylation | Uniprot | |
| Y89 | Phosphorylation | Uniprot | |
| T120 | Phosphorylation | Uniprot | |
| T123 | Phosphorylation | Uniprot | |
| S125 | Phosphorylation | Uniprot | |
| T139 | Phosphorylation | Uniprot | |
| S143 | Phosphorylation | Uniprot | |
| K146 | Acetylation | Uniprot | |
| K146 | Ubiquitination | Uniprot | |
| Y154 | Phosphorylation | Uniprot | |
| T164 | Phosphorylation | Uniprot | |
| K166 | Ubiquitination | Uniprot | |
| K182 | Ubiquitination | Uniprot |
研究背景
Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).
Endoplasmic reticulum. Golgi apparatus.
Interacts with B3GAT1.
Belongs to the small GTPase superfamily. SAR1 family.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Legionellosis.
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