| 产品: | GBP5 抗体 |
| 货号: | DF9568 |
| 描述: | Rabbit polyclonal antibody to GBP5 |
| 应用: | WB |
| 反应: | Human |
| 分子量: | 67 kDa; 67kD(Calculated). |
| 蛋白号: | Q96PP8 |
| RRID: | AB_2842764 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9568, RRID:AB_2842764.
展开/折叠
GBP 5; GBP TA antigen; GBP-5; GBP-TA antigen; GBP5; GBP5_HUMAN; GTP binding protein 5; GTP-binding protein 5; Guanine nucleotide binding protein 5; Guanine nucleotide-binding protein 5; Guanylate binding protein 5; Guanylate-binding protein 5; UNQ2427/PRO4987;
抗原和靶标
- Q96PP8 GBP5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTLRDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCVLL
翻译修饰 - Q96PP8 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S52 | Phosphorylation | Uniprot | |
| S157 | Phosphorylation | Uniprot | |
| K226 | Acetylation | Uniprot | |
| K380 | Ubiquitination | Uniprot | |
| K389 | Ubiquitination | Uniprot | |
| K533 | Ubiquitination | Uniprot | |
| S565 | Phosphorylation | Uniprot |
研究背景
As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP.
Isoprenylation is required for proper subcellular location.
Cytoplasm. Golgi apparatus membrane>Lipid-anchor.
Expressed in peripheral blood monocytes (at protein level).
Homodimer. Heterodimer with other family members, including GBP1, GBP2, GBP3 and GBP4. Dimerization is nucleotide-dependent; isoform 1 and isoform 2 form dimers when GTP-bound. GDP-bound isoform 2 is monomeric, while isoform 1 remains dimeric. Dimerization regulates subcellular location. May also form tetramers (dimer of dimers) in the presence of GTP. Interacts with NLRP3, possibly in its tetrameric form, and promotes PYCARD/ASC polymerization.
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
研究领域
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
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