| 产品: | NKX22 抗体 |
| 货号: | DF9587 |
| 描述: | Rabbit polyclonal antibody to NKX22 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Rabbit, Dog, Xenopus |
| 分子量: | 30 kDa; 30kD(Calculated). |
| 蛋白号: | O95096 |
| RRID: | AB_2842783 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9587, RRID:AB_2842783.
展开/折叠
Homeobox protein NK 2 homolog B; Homeobox protein NK-2 homolog B; Homeobox protein Nkx 2.2; Homeobox protein Nkx-2.2; NK 2 homolog B; NK2 homeobox 2; NK2 transcription factor like protein B; NK2 transcription factor related locus 2; NKX2 2; NKX2-2; NKX22; NKX22_HUMAN; Nkx2b; tinman;
抗原和靶标
- O95096 NKX22_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLTNTKTGFSVKDILDLPDTNDEEGSVAEGPEEENEGPEPAKRAGPLGQGALDAVQSLPLKNPFYDSSDNPYTRWLASTEGLQYSLHGLAAGAPPQDSSSKSPEPSADESPDNDKETPGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRVAVPVLVRDGKPCHALKAQDLAAATFQAGIPFSAYSAQSLQHMQYNAQYSSASTPQYPTAHPLVQAQQWTW
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O95096 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T6 | Phosphorylation | Uniprot | |
| T8 | Phosphorylation | Uniprot | |
| S11 | Phosphorylation | Uniprot | |
| S58 | Phosphorylation | Uniprot | |
| K137 | Ubiquitination | Uniprot | |
| Y152 | Phosphorylation | Uniprot | |
| S163 | Phosphorylation | Uniprot | |
| S199 | Phosphorylation | Uniprot |
研究背景
Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity).
Nucleus.
Interacts with OLIG2.
The homeodomain is essential for interaction with OLIG2.
Belongs to the NK-2 homeobox family.
研究领域
· Human Diseases > Endocrine and metabolic diseases > Maturity onset diabetes of the young.
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