| 产品: | ACSL3 抗体 |
| 货号: | DF9606 |
| 描述: | Rabbit polyclonal antibody to ACSL3 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 70 kDa; 80kD(Calculated). |
| 蛋白号: | O95573 |
| RRID: | AB_2842802 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9606, RRID:AB_2842802.
展开/折叠
ACS3; Acsl3; ACSL3_HUMAN; Acyl CoA synthetase long chain family member 3; FACL3; Fatty acid Coenzyme A ligase long chain 3; LACS 3; LACS3; Lignoceroyl CoA synthase; Long chain acyl CoA synthetase 3; Long chain fatty acid CoA ligase 3; Long-chain acyl-CoA synthetase 3; Long-chain-fatty-acid--CoA ligase 3; PRO2194;
抗原和靶标
- O95573 ACSL3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O95573 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S6 | Phosphorylation | Uniprot | |
| K13 | Ubiquitination | Uniprot | |
| K56 | Ubiquitination | Uniprot | |
| K58 | Ubiquitination | Uniprot | |
| K63 | Ubiquitination | Uniprot | |
| K90 | Ubiquitination | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| T107 | Phosphorylation | Uniprot | |
| K122 | Acetylation | Uniprot | |
| K122 | Ubiquitination | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| C166 | S-Nitrosylation | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| K240 | Ubiquitination | Uniprot | |
| Y351 | Phosphorylation | Uniprot | |
| S353 | Phosphorylation | Uniprot | |
| K363 | Ubiquitination | Uniprot | |
| K376 | Ubiquitination | Uniprot | |
| K392 | Ubiquitination | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| K422 | Ubiquitination | Uniprot | |
| C450 | S-Nitrosylation | Uniprot | |
| K507 | Ubiquitination | Uniprot | |
| K509 | Ubiquitination | Uniprot | |
| Y516 | Phosphorylation | Uniprot | |
| K521 | Acetylation | Uniprot | |
| K521 | Ubiquitination | Uniprot | |
| K547 | Ubiquitination | Uniprot | |
| C561 | S-Nitrosylation | Uniprot | |
| C573 | S-Nitrosylation | Uniprot | |
| K575 | Ubiquitination | Uniprot | |
| Y591 | Phosphorylation | Uniprot | |
| S593 | Phosphorylation | Uniprot | |
| K596 | Ubiquitination | Uniprot | |
| K642 | Ubiquitination | Uniprot | |
| K673 | Ubiquitination | Uniprot | |
| K679 | Ubiquitination | Uniprot | |
| S683 | Phosphorylation | Uniprot | |
| T688 | Phosphorylation | Uniprot | |
| T691 | Phosphorylation | Uniprot | |
| T695 | Phosphorylation | Uniprot | |
| K699 | Acetylation | Uniprot | |
| K699 | Ubiquitination | Uniprot | |
| K706 | Acetylation | Uniprot | |
| K706 | Ubiquitination | Uniprot | |
| Y709 | Phosphorylation | Uniprot |
研究背景
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity).
Mitochondrion outer membrane>Single-pass type III membrane protein. Peroxisome membrane>Single-pass type III membrane protein. Microsome membrane>Single-pass type III membrane protein. Endoplasmic reticulum membrane>Single-pass type III membrane protein.
Belongs to the ATP-dependent AMP-binding enzyme family.
研究领域
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
· Cellular Processes > Cell growth and death > Ferroptosis. (View pathway)
· Metabolism > Lipid metabolism > Fatty acid biosynthesis.
· Metabolism > Lipid metabolism > Fatty acid degradation.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Fatty acid metabolism.
· Organismal Systems > Endocrine system > PPAR signaling pathway.
· Organismal Systems > Endocrine system > Adipocytokine signaling pathway.
限制条款
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