产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9608, RRID:AB_2842804.
展开/折叠
AI848829; FLJ12929; Low density lipoprotein receptor related protein 12; Low-density lipoprotein receptor-related protein 12; LRP 12; LRP-12; LRP12; LRP12_HUMAN; ST7; Suppressor of tumorigenicity 7 protein;
抗原和靶标
Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines.
- Q9Y561 LRP12_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MACRWSTKESPRWRSALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAELLRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSSNIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENERRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVSPARHQLTSALSRMTQGLRWVRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPISDGSSDFDVNDCSRPLLDLASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDTCLEVTLKNETSDDEALLLC
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9Y561 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S6 | Phosphorylation | Uniprot | |
| T7 | Phosphorylation | Uniprot | |
| K160 | Ubiquitination | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| K305 | Ubiquitination | Uniprot | |
| K316 | Ubiquitination | Uniprot | |
| K327 | Ubiquitination | Uniprot | |
| K358 | Ubiquitination | Uniprot | |
| K415 | Ubiquitination | Uniprot | |
| S430 | Phosphorylation | Uniprot | |
| R432 | Methylation | Uniprot | |
| Y435 | Phosphorylation | Uniprot | |
| T495 | Phosphorylation | Uniprot | |
| S501 | Phosphorylation | Uniprot | |
| T515 | Phosphorylation | Uniprot | |
| S584 | Phosphorylation | Uniprot | |
| T589 | Phosphorylation | Uniprot | |
| S617 | Phosphorylation | Uniprot | |
| S631 | Phosphorylation | Uniprot | |
| S652 | Phosphorylation | Uniprot | |
| T655 | Phosphorylation | Uniprot | |
| T657 | Phosphorylation | Uniprot | |
| K678 | Ubiquitination | Uniprot | |
| S720 | Phosphorylation | Uniprot | |
| S749 | Phosphorylation | Uniprot | |
| S755 | Phosphorylation | Uniprot | |
| S851 | Phosphorylation | Uniprot |
研究背景
Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.
Membrane>Single-pass type I membrane protein. Membrane>Coated pit.
Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines.
May interact with RACK1, ZFYVE9 and NMRK2.
Belongs to the LDLR family.
限制条款
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