| 产品: | MARVELD2 抗体 |
| 货号: | DF9611 |
| 描述: | Rabbit polyclonal antibody to MARVELD2 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 分子量: | 64 kDa; 64kD(Calculated). |
| 蛋白号: | Q8N4S9 |
| RRID: | AB_2842807 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9611, RRID:AB_2842807.
展开/折叠
DFNB49; FLJ30532; MARVD2; MARVEL (membrane associating) domain containing 2; MARVEL domain containing 2; MARVEL domain containing protein 2; MARVELD 2; MARVELD2; MRVLDC2; Tric; Tricellulin;
抗原和靶标
- Q8N4S9 MALD2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSNDGRSRNRDRRYDEVPSDLPYQDTTIRTHPTLHDSERAVSADPLPPPPLPLQPPFGPDFYSSDTEEPAIAPDLKPVRRFVPDSWKNFFRGKKKDPEWDKPVSDIRYISDGVECSPPASPARPNHRSPLNSCKDPYGGSEGTFSSRKEADAVFPRDPYGSLDRHTQTVRTYSEKVEEYNLRYSYMKSWAGLLRILGVVELLLGAGVFACVTAYIHKDSEWYNLFGYSQPYGMGGVGGLGSMYGGYYYTGPKTPFVLVVAGLAWITTIIILVLGMSMYYRTILLDSNWWPLTEFGINVALFILYMAAAIVYVNDTNRGGLCYYPLFNTPVNAVFCRVEGGQIAAMIFLFVTMIVYLISALVCLKLWRHEAARRHREYMEQQEINEPSLSSKRKMCEMATSGDRQRDSEVNFKELRTAKMKPELLSGHIPPGHIPKPIVMPDYVAKYPVIQTDDERERYKAVFQDQFSEYKELSAEVQAVLRKFDELDAVMSRLPHHSESRQEHERISRIHEEFKKKKNDPTFLEKKERCDYLKNKLSHIKQRIQEYDKVMNWDVQGYS
翻译修饰 - Q8N4S9 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y14 | Phosphorylation | Uniprot | |
| Y23 | Phosphorylation | Uniprot | |
| T26 | Phosphorylation | Uniprot | |
| T27 | Phosphorylation | Uniprot | |
| S37 | Phosphorylation | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| K101 | Ubiquitination | Uniprot | |
| S104 | Phosphorylation | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| Y137 | Phosphorylation | Uniprot | |
| S140 | Phosphorylation | Uniprot | |
| S146 | Phosphorylation | Uniprot | |
| K148 | Ubiquitination | Uniprot | |
| Y159 | Phosphorylation | Uniprot | |
| S161 | Phosphorylation | Uniprot | |
| T166 | Phosphorylation | Uniprot | |
| T168 | Phosphorylation | Uniprot | |
| S173 | Phosphorylation | Uniprot | |
| K175 | Ubiquitination | Uniprot | |
| Y377 | Phosphorylation | Uniprot | |
| S387 | Phosphorylation | Uniprot | |
| K391 | Ubiquitination | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| K412 | Ubiquitination | Uniprot | |
| Y442 | Phosphorylation | Uniprot | |
| Y446 | Phosphorylation | Uniprot | |
| S467 | Phosphorylation | Uniprot | |
| Y469 | Phosphorylation | Uniprot | |
| K548 | Ubiquitination | Uniprot | |
| Y557 | Phosphorylation | Uniprot | |
| S558 | Phosphorylation | Uniprot |
研究背景
Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti.
Ubiquitinated by ITCH; but this ubiquitination does not lead to proteasomal degradation.
Phosphorylated.
Cell membrane>Multi-pass membrane protein. Cell junction>Tight junction.
Note: Found at tricellular contacts.
Interacts with TJP1. Interacts with the ubiquitin ligase ITCH.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)
限制条款
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