产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9658, RRID:AB_2842854.
展开/折叠
GCCD4; mitochondrial; NAD(P) transhydrogenase; NAD(P) transhydrogenase mitochondrial; Nicotinamide nucleotide transhydrogenase; NNT; NNTM; NNTM_HUMAN; Pyridine nucleotide transhydrogenase;
抗原和靶标
Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues.
- Q13423 NNTM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MANLLKTVVTGCSCPLLSNLGSCKGLRVKKDFLRTFYTHQELWCKAPVKPGIPYKQLTVGVPKEIFQNEKRVALSPAGVQNLVKQGFNVVVESGAGEASKFSDDHYRVAGAQIQGAKEVLASDLVVKVRAPMVNPTLGVHEADLLKTSGTLISFIYPAQNPELLNKLSQRKTTVLAMDQVPRVTIAQGYDALSSMANIAGYKAVVLAANHFGRFFTGQITAAGKVPPAKILIVGGGVAGLASAGAAKSMGAIVRGFDTRAAALEQFKSLGAEPLEVDLKESGEGQGGYAKEMSKEFIEAEMKLFAQQCKEVDILISTALIPGKKAPVLFNKEMIESMKEGSVVVDLAAEAGGNFETTKPGELYIHKGITHIGYTDLPSRMATQASTLYSNNITKLLKAISPDKDNFYFDVKDDFDFGTMGHVIRGTVVMKDGKVIFPAPTPKNIPQGAPVKQKTVAELEAEKAATITPFRKTMSTASAYTAGLTGILGLGIAAPNLAFSQMVTTFGLAGIVGYHTVWGVTPALHSPLMSVTNAISGLTAVGGLALMGGHLYPSTTSQGLAALAAFISSVNIAGGFLVTQRMLDMFKRPTDPPEYNYLYLLPAGTFVGGYLAALYSGYNIEQIMYLGSGLCCVGALAGLSTQGTARLGNALGMIGVAGGLAATLGVLKPGPELLAQMSGAMALGGTIGLTIAKRIQISDLPQLVAAFHSLVGLAAVLTCIAEYIIEYPHFATDAAANLTKIVAYLGTYIGGVTFSGSLIAYGKLQGLLKSAPLLLPGRHLLNAGLLAASVGGIIPFMVDPSFTTGITCLGSVSALSAVMGVTLTAAIGGADMPVVITVLNSYSGWALCAEGFLLNNNLLTIVGALIGSSGAILSYIMCVAMNRSLANVILGGYGTTSTAGGKPMEISGTHTEINLDNAIDMIREANSIIITPGYGLCAAKAQYPIADLVKMLTEQGKKVRFGIHPVAGRMPGQLNVLLAEAGVPYDIVLEMDEINHDFPDTDLVLVIGANDTVNSAAQEDPNSIIAGMPVLEVWKSKQVIVMKRSLGVGYAAVDNPIFYKPNTAMLLGDAKKTCDALQAKVRESYQK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q13423 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K49 | Ubiquitination | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| K63 | Acetylation | Uniprot | |
| K70 | Acetylation | Uniprot | |
| S75 | Phosphorylation | Uniprot | |
| K100 | Acetylation | Uniprot | |
| K117 | Acetylation | Uniprot | |
| S122 | Phosphorylation | Uniprot | |
| T150 | Phosphorylation | Uniprot | |
| K202 | Acetylation | Uniprot | |
| K267 | Ubiquitination | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| K323 | Acetylation | Uniprot | |
| K331 | Acetylation | Uniprot | |
| T369 | Phosphorylation | Uniprot | |
| Y373 | Phosphorylation | Uniprot | |
| T374 | Phosphorylation | Uniprot | |
| T382 | Phosphorylation | Uniprot | |
| T393 | Phosphorylation | Uniprot | |
| K394 | Acetylation | Uniprot | |
| K397 | Acetylation | Uniprot | |
| K403 | Ubiquitination | Uniprot | |
| Y407 | Phosphorylation | Uniprot | |
| T440 | Phosphorylation | Uniprot | |
| K442 | Ubiquitination | Uniprot | |
| K451 | Ubiquitination | Uniprot | |
| K462 | Ubiquitination | Uniprot | |
| S677 | Phosphorylation | Uniprot | |
| S769 | Phosphorylation | Uniprot | |
| Y942 | Phosphorylation | Uniprot | |
| K1059 | Acetylation | Uniprot | |
| K1070 | Acetylation | Uniprot | |
| K1071 | Acetylation | Uniprot | |
| K1079 | Ubiquitination | Uniprot |
研究背景
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.
Mitochondrion inner membrane>Multi-pass membrane protein>Matrix side.
Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues.
Homodimer.
In the N-terminal section; belongs to the AlaDH/PNT family.
In the C-terminal section; belongs to the PNT beta subunit family.
研究领域
· Metabolism > Metabolism of cofactors and vitamins > Nicotinate and nicotinamide metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
限制条款
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