产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9663, RRID:AB_2842859.
展开/折叠
B12; CI B12; CI-B12; Complex I B12; Complex I-B12; NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 12kDa; NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3; NADH ubiquinone oxidoreductase B12 subunit; NADH-ubiquinone oxidoreductase 1 beta subcomplex, 3; NADH-ubiquinone oxidoreductase B12 subunit; NADH:ubiquinone oxidoreductase subunit B3; NDUB3_HUMAN; NDUFB 3; NDUFB3;
抗原和靶标
- O43676 NDUB3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAHEHGHEHGHHKMELPDYRQWKIEGTPLETIQKKLAAKGLRDPWGRNEAWRYMGGFAKSVSFSDVFFKGFKWGFAAFVVAVGAEYYLESLNKDKKHH
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O43676 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K23 | Acetylation | Uniprot | |
| K23 | Ubiquitination | Uniprot | |
| K34 | Acetylation | Uniprot | |
| K35 | Acetylation | Uniprot | |
| K39 | Methylation | Uniprot | |
| K59 | Methylation | Uniprot | |
| S60 | Phosphorylation | Uniprot |
研究背景
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Mitochondrion inner membrane>Single-pass membrane protein>Matrix side.
Complex I is composed of 45 different subunits.
Belongs to the complex I NDUFB3 subunit family.
研究领域
· Human Diseases > Endocrine and metabolic diseases > Non-alcoholic fatty liver disease (NAFLD).
· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.
· Human Diseases > Neurodegenerative diseases > Parkinson's disease.
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Metabolism > Energy metabolism > Oxidative phosphorylation.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Nervous system > Retrograde endocannabinoid signaling. (View pathway)
限制条款
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