| 产品: | NUP155 抗体 |
| 货号: | DF9708 |
| 描述: | Rabbit polyclonal antibody to NUP155 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat, Monkey |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 130,155 kDa; 155kD(Calculated). |
| 蛋白号: | O75694 |
| RRID: | AB_2842903 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9708, RRID:AB_2842903.
展开/折叠
155 kDa nucleoporin; ATFB15; D930027M19Rik; KIAA0791; mKIAA0791; N155; NU155_HUMAN; Nuclear pore complex protein Nup155; nucleoporin 155kD; Nucleoporin Nup155; Nup155;
抗原和靶标
Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
- O75694 NU155_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPSSLLGAAMPASTSAAALQEALENAGRLIDRQLQEDRMYPDLSELLMVSAPNNPTVSGMSDMDYPLQGPGLLSVPNLPEISSIRRVPLPPELVEQFGHMQCNCMMGVFPPISRAWLTIDSDIFMWNYEDGGDLAYFDGLSETILAVGLVKPKAGIFQPHVRHLLVLATPVDIVILGLSYANLQTGSGVLNDSLSGGMQLLPDPLYSLPTDNTYLLTITSTDNGRIFLAGKDGCLYEVAYQAEAGWFSQRCRKINHSKSSLSFLVPSLLQFTFSEDDPILQIAIDNSRNILYTRSEKGVIQVYDLGQDGQGMSRVASVSQNAIVSAAGNIARTIDRSVFKPIVQIAVIENSESLDCQLLAVTHAGVRLYFSTCPFRQPLARPNTLTLVHVRLPPGFSASSTVEKPSKVHRALYSKGILLMAASENEDNDILWCVNHDTFPFQKPMMETQMTAGVDGHSWALSAIDELKVDKIITPLNKDHIPITDSPVVVQQHMLPPKKFVLLSAQGSLMFHKLRPVDQLRHLLVSNVGGDGEEIERFFKLHQEDQACATCLILACSTAACDREVSAWATRAFFRYGGEAQMRFPTTLPPPSNVGPILGSPVYSSSPVPSGSPYPNPSFLGTPSHGIQPPAMSTPVCALGNPATQATNMSCVTGPEIVYSGKHNGICIYFSRIMGNIWDASLVVERIFKSGNREITAIESSVPCQLLESVLQELKGLQEFLDRNSQFAGGPLGNPNTTAKVQQRLIGFMRPENGNPQQMQQELQRKFHEAQLSEKISLQAIQQLVRKSYQALALWKLLCEHQFTIIVAELQKELQEQLKITTFKDLVIRDKELTGALIASLINCYIRDNAAVDGISLHLQDICPLLYSTDDAICSKANELLQRSRQVQNKTEKERMLRESLKEYQKISNQVDLSNVCAQYRQVRFYEGVVELSLTAAEKKDPQGLGLHFYKHGEPEEDIVGLQAFQERLNSYKCITDTLQELVNQSKAAPQSPSVPKKPGPPVLSSDPNMLSNEEAGHHFEQMLKLSQRSKDELFSIALYNWLIQVDLADKLLQVASPFLEPHLVRMAKVDQNRVRYMDLLWRYYEKNRSFSNAARVLSRLADMHSTEISLQQRLEYIARAILSAKSSTAISSIAADGEFLHELEEKMEVARIQLQIQETLQRQYSHHSSVQDAVSQLDSELMDITKLYGEFADPFKLAECKLAIIHCAGYSDPILVQTLWQDIIEKELSDSVTLSSSDRMHALSLKIVLLGKIYAGTPRFFPLDFIVQFLEQQVCTLNWDVGFVIQTMNEIGVPLPRLLEVYDQLFKSRDPFWNRMKKPLHLLDCIHVLLIRYVENPSQVLNCERRRFTNLCLDAVCGYLVELQSMSSSVAVQAITGNFKSLQAKLERLH
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O75694 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S3 | Phosphorylation | Uniprot | |
| S4 | Phosphorylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| S15 | Phosphorylation | Uniprot | |
| K297 | Ubiquitination | Uniprot | |
| S313 | Phosphorylation | Uniprot | |
| K407 | Ubiquitination | Uniprot | |
| K471 | Ubiquitination | Uniprot | |
| T474 | Phosphorylation | Uniprot | |
| K478 | Ubiquitination | Uniprot | |
| S486 | Phosphorylation | Uniprot | |
| K498 | Ubiquitination | Uniprot | |
| S504 | Phosphorylation | Uniprot | |
| S508 | Phosphorylation | Uniprot | |
| K540 | Ubiquitination | Uniprot | |
| S681 | Phosphorylation | Uniprot | |
| S690 | Phosphorylation | Uniprot | |
| R723 | Methylation | Uniprot | |
| S725 | Phosphorylation | Uniprot | |
| K740 | Ubiquitination | Uniprot | |
| K766 | Sumoylation | Uniprot | |
| K766 | Ubiquitination | Uniprot | |
| K775 | Ubiquitination | Uniprot | |
| K819 | Ubiquitination | Uniprot | |
| K824 | Ubiquitination | Uniprot | |
| K890 | Ubiquitination | Uniprot | |
| K893 | Ubiquitination | Uniprot | |
| K902 | Ubiquitination | Uniprot | |
| K906 | Ubiquitination | Uniprot | |
| S914 | Phosphorylation | Uniprot | |
| Y926 | Phosphorylation | Uniprot | |
| K940 | Ubiquitination | Uniprot | |
| K951 | Ubiquitination | Uniprot | |
| K973 | Ubiquitination | Uniprot | |
| C974 | S-Nitrosylation | Uniprot | |
| K987 | Ubiquitination | Uniprot | |
| S992 | Phosphorylation | Uniprot | |
| S994 | Phosphorylation | Uniprot | |
| K998 | Ubiquitination | Uniprot | |
| K1025 | Ubiquitination | Uniprot | |
| S1030 | Phosphorylation | Uniprot | |
| S1057 | Phosphorylation | Uniprot | |
| K1069 | Ubiquitination | Uniprot | |
| Y1084 | Phosphorylation | Uniprot | |
| Y1085 | Phosphorylation | Uniprot | |
| S1090 | Phosphorylation | Uniprot | |
| S1092 | Phosphorylation | Uniprot | |
| S1099 | Phosphorylation | Uniprot | |
| K1126 | Ubiquitination | Uniprot | |
| K1147 | Ubiquitination | Uniprot | |
| S1166 | Phosphorylation | Uniprot | |
| K1197 | Ubiquitination | Uniprot | |
| K1308 | Ubiquitination | Uniprot | |
| K1386 | Sumoylation | Uniprot | |
| K1386 | Ubiquitination | Uniprot |
研究背景
Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.
Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis (By similarity).
Disulfide-linked to NUP62. The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC (By similarity).
Nucleus>Nuclear pore complex. Nucleus membrane>Peripheral membrane protein>Cytoplasmic side. Nucleus membrane>Peripheral membrane protein>Nucleoplasmic side.
Note: In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis.
Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Interacts with GLE1. Able to form a heterotrimer with GLE1 and NUP42 in vitro. Forms a complex with NUP35, NUP93, NUP205 and lamin B.
Belongs to the non-repetitive/WGA-negative nucleoporin family.
研究领域
· Genetic Information Processing > Translation > RNA transport.
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