| 产品: | NVL 抗体 |
| 货号: | DF9714 |
| 描述: | Rabbit polyclonal antibody to NVL |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 分子量: | 95 kDa; 95kD(Calculated). |
| 蛋白号: | O15381 |
| RRID: | AB_2842909 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9714, RRID:AB_2842909.
展开/折叠
Nuclear valosin containing protein like; Nuclear valosin-containing protein-like; Nuclear VCP like; Nuclear VCP-like protein; Nvl; NVL_HUMAN; NVLp; OTTHUMP00000035641; OTTHUMP00000216593; OTTHUMP00000216594; OTTHUMP00000216599; OTTHUMP00000216600;
抗原和靶标
Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.
- O15381 NVL_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYERLQESLSR
翻译修饰 - O15381 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K12 | Ubiquitination | Uniprot | |
| S23 | Phosphorylation | Uniprot | |
| K25 | Ubiquitination | Uniprot | |
| Y29 | Phosphorylation | Uniprot | |
| S37 | Phosphorylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| K70 | Acetylation | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| K73 | Ubiquitination | Uniprot | |
| T76 | Phosphorylation | Uniprot | |
| K85 | Ubiquitination | Uniprot | |
| K129 | Acetylation | Uniprot | |
| K129 | Ubiquitination | Uniprot | |
| S134 | Phosphorylation | Uniprot | |
| T138 | Phosphorylation | Uniprot | |
| T147 | Phosphorylation | Uniprot | |
| S149 | Phosphorylation | Uniprot | |
| T150 | Phosphorylation | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| T164 | Phosphorylation | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| T178 | Phosphorylation | Uniprot | |
| S180 | Phosphorylation | Uniprot | |
| S185 | Phosphorylation | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| S195 | Phosphorylation | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| S207 | Phosphorylation | Uniprot | |
| K208 | Sumoylation | Uniprot | |
| S210 | Phosphorylation | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| S215 | Phosphorylation | Uniprot | |
| Y290 | Phosphorylation | Uniprot | |
| K345 | Ubiquitination | Uniprot | |
| S355 | Phosphorylation | Uniprot | |
| K492 | Ubiquitination | Uniprot | |
| K498 | Acetylation | Uniprot | |
| K499 | Ubiquitination | Uniprot | |
| K509 | Ubiquitination | Uniprot | |
| Y655 | Phosphorylation | Uniprot | |
| K671 | Ubiquitination | Uniprot | |
| K759 | Ubiquitination | Uniprot | |
| S801 | Phosphorylation | Uniprot | |
| S814 | Phosphorylation | Uniprot | |
| K826 | Ubiquitination | Uniprot | |
| S837 | Phosphorylation | Uniprot | |
| S838 | Phosphorylation | Uniprot | |
| S840 | Phosphorylation | Uniprot |
研究背景
Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity.
Nucleus>Nucleoplasm.
Nucleus>Nucleolus. Nucleus>Nucleoplasm.
Note: Expressed predominantly in the nucleolus. Associates with pre-ribosomal particles in the nucleus.
Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.
Interacts with NCL/nucleolin. Isoform 1 and isoform 2 interact with TERT and isoform 1 exhibits a higher binding affinity for TERT compared to isoform 2. Isoform 1 interacts with MTREX in an ATP-dependent manner; the interaction is required to associate NVL with nuclear RNA exosome. Isoform 1 interacts with RPL5 in an ATP-dependent manner. Interacts with WDR74 (through WDR repeats); the interaction is independent of RNA or pre-60S ribosome particles.
Belongs to the AAA ATPase family.
研究领域
· Genetic Information Processing > Translation > Ribosome biogenesis in eukaryotes.
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