SLC22A4 Antibody - #DF9724

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产品: SLC22A4 抗体
货号: DF9724
描述: Rabbit polyclonal antibody to SLC22A4
应用: WB
文献验证: WB
反应: Human, Mouse
蛋白号: Q9H015
RRID: AB_2842919

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse
克隆:
Polyclonal
特异性:
SLC22A4 Antibody detects endogenous levels of total SLC22A4.
RRID:
AB_2842919
引用格式: Affinity Biosciences Cat# DF9724, RRID:AB_2842919.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Ergothioneine transporter; ET transporter; integral membrane transport protein; LSTP Like 2; MGC34546; MGC40524; Octn1; Organic cation transporter 1; Organic cation/carnitine transporter 1; RP23-354D12.1; S22A4_HUMAN; Slc22a4; Solute carrier family (organic cation transporter), member 4; solute carrier family 22 (organic cation/zwitterion transporter), member 4; Solute carrier family 22 member 4;

抗原和靶标

免疫原:

A synthesized peptide derived from human SLC22A4, corresponding to a region within C-terminal amino acids.

基因/基因ID:
SLC22A4(6583)

研究领域

· Human Diseases > Cancers: Overview > Choline metabolism in cancer.   (View pathway)

文献引用

1). Cigarette smoke extract combined with lipopolysaccharide reduces OCTN1/2 expression in human alveolar epithelial cells in vitro and rat lung in vivo under inflammatory conditions. International Immunopharmacology, 2020 (PubMed: 32707498) [IF=4.8]

Application: WB    Species: human    Sample: A549 cells

Fig. 6. |The protein expression of OCTN1/2 and inflammatory factors in A549 cells at different concentrations. (A) The expression of OCTN1/2, IL-6, TNF-α, and IL1β in A549 cells was determined by western blot.
2). LPS-induced inflammation delays the transportation of ASP+ due to down-regulation of OCTN1/2 in alveolar epithelial cells. JOURNAL OF DRUG TARGETING, 2020 (PubMed: 31591905) [IF=4.3]

Application: WB    Species: human    Sample: A549 cells

Fig.2.| LPS regulates the level of OCTN1/2 and inflammation in a non-dose dependent manner in A549 cells. After cells were induced by different concentrations of LPS (0, 2, 10, 50, and 250 μg/mL) for 24 h, the expression of OCTN1 (62 kDa), OCTN2 (63 kDa), IL6 (24 kDa), IL18 (26 kDa), IL1β (31 kDa),and TNF-α (26 kDa) was significantly regulated in human respiratory epithelial cells;β-actin (42 kDa) was used as a loading control. Bands were analysed using ImageJ 1.45s (National Institutes of Health, USA). NC indicates the normal control groups. Data are shown as the mean ± SD (n = 3).

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