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| 产品: | P2RX1 抗体 |
| 货号: | DF9728 |
| 描述: | Rabbit polyclonal antibody to P2RX1 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 45 kDa; 45kD(Calculated). |
| 蛋白号: | P51575 |
| RRID: | AB_2842923 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9728, RRID:AB_2842923.
展开/折叠
ATP receptor; H.sapiens mRNA for ATP receptor; P2 RX1; P2rx1; P2RX1 protein; P2RX1_HUMAN; P2X purinoceptor 1; P2X receptor subunit 1; P2X1; P2X1 receptor; Purinergic receptor; Purinergic receptor P2X ligand gated ion channel 1; Purinergic receptor P2X1;
抗原和靶标
- P51575 P2RX1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSGLISSVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEHPEGGICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLREAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESGQNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNLSPGFNFRFARHFVENGTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKFKYAEDMGPGAAERDLAATSSTLGLQENMRTS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P51575 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y16 | Phosphorylation | Uniprot | |
| T18 | Phosphorylation | Uniprot | |
| S130 | Phosphorylation | Uniprot | |
| K138 | Acetylation | Uniprot | |
| Y274 | Phosphorylation | Uniprot | |
| S286 | Phosphorylation | Uniprot | |
| Y370 | Phosphorylation | Uniprot | |
| T386 | Phosphorylation | Uniprot | |
| S387 | Phosphorylation | Uniprot | |
| S388 | Phosphorylation | Uniprot | |
| T389 | Phosphorylation | Uniprot | |
| T398 | Phosphorylation | Uniprot | |
| S399 | Phosphorylation | Uniprot |
研究背景
Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity).
Membrane>Multi-pass membrane protein.
Homo- or heteropolymers.
Belongs to the P2X receptor family.
研究领域
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Organismal Systems > Immune system > Platelet activation. (View pathway)
文献引用
Application: WB Species: Human Sample: breast cancer cell
限制条款
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