| 产品: | PEX5 抗体 |
| 货号: | DF9737 |
| 描述: | Rabbit polyclonal antibody to PEX5 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 71 kDa; 71kD(Calculated). |
| 蛋白号: | P50542 |
| RRID: | AB_2842932 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9737, RRID:AB_2842932.
展开/折叠
FLJ50634; FLJ50721; FLJ51948; PBD2A; PBD2B; Peroxin 5; Peroxin-5; Peroxisomal biogenesis factor 5; Peroxisomal C terminal targeting signal import receptor; Peroxisomal C-terminal targeting signal import receptor; Peroxisomal targeting signal 1 (SKL type) receptor; Peroxisomal targeting signal 1 receptor; Peroxisomal targeting signal import receptor; Peroxisomal targeting signal receptor 1; Peroxisome receptor 1; pex5; PEX5_HUMAN; PTS1 BP; PTS1 receptor; PTS1-BP; PTS1R; PXR1;
抗原和靶标
Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
- P50542 PEX5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAMRELVEAECGGANPLMKLAGHFTQDKALRQEGLRPGPWPPGAPASEAASKPLGVASEDELVAEFLQDQNAPLVSRAPQTFKMDDLLAEMQQIEQSNFRQAPQRAPGVADLALSENWAQEFLAAGDAVDVTQDYNETDWSQEFISEVTDPLSVSPARWAEEYLEQSEEKLWLGEPEGTATDRWYDEYHPEEDLQHTASDFVAKVDDPKLANSEFLKFVRQIGEGQVSLESGAGSGRAQAEQWAAEFIQQQGTSDAWVDQFTRPVNTSALDMEFERAKSAIESDVDFWDKLQAELEEMAKRDAEAHPWLSDYDDLTSATYDKGYQFEEENPLRDHPQPFEEGLRRLQEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSRGPRGEGGAMSENIWSTLRLALSMLGQSDAYGAADARDLSTLLTMFGLPQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P50542 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K19 | Ubiquitination | Uniprot | |
| K28 | Acetylation | Uniprot | |
| K28 | Ubiquitination | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| S58 | Phosphorylation | Uniprot | |
| K83 | Ubiquitination | Uniprot | |
| S115 | Phosphorylation | Uniprot | |
| S141 | Phosphorylation | Q13315 (ATM) | Uniprot |
| T149 | Phosphorylation | Uniprot | |
| S153 | Phosphorylation | Uniprot | |
| S155 | Phosphorylation | Uniprot | |
| Y163 | Phosphorylation | Uniprot | |
| S167 | Phosphorylation | Uniprot | |
| Y185 | Phosphorylation | Uniprot | |
| Y188 | Phosphorylation | Uniprot | |
| K204 | Ubiquitination | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| K217 | Ubiquitination | Uniprot | |
| S228 | Phosphorylation | Uniprot | |
| K278 | Ubiquitination | Uniprot | |
| S279 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | Uniprot | |
| K290 | Ubiquitination | Uniprot | |
| K300 | Ubiquitination | Uniprot | |
| S310 | Phosphorylation | Uniprot | |
| Y312 | Phosphorylation | Uniprot | |
| S317 | Phosphorylation | Uniprot | |
| K322 | Ubiquitination | Uniprot | |
| K456 | Ubiquitination | Uniprot | |
| K527 | Ubiquitination | Uniprot | |
| T633 | Phosphorylation | Uniprot |
研究背景
Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.
Monoubiquitination at Cys-11 is required for proper export from peroxisomes and recycling.
Cytoplasm. Peroxisome membrane>Peripheral membrane protein.
Note: Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane through a docking factor (PEX13).
Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Interacts with PEX7 and PEX13 (By similarity). Interacts with PEX12 and PEX14. Interacts (Cys-linked ubiquitinated) with ZFAND6. Interacts with VWA8 in a PEX7-dependent manner (By similarity).
Belongs to the peroxisomal targeting signal receptor family.
研究领域
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
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