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产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9757, RRID:AB_2842952.
展开/折叠
AT2B2_HUMAN; atp2b2; ATPase plasma membrane Ca2+ transporting 2; Plasma membrane calcium ATPase 2; Plasma membrane calcium ATPase; Plasma membrane calcium ATPase isoform 2; Plasma membrane calcium pump isoform 2; Plasma membrane calcium transporting ATPase 2; Plasma membrane calcium-transporting ATPase 2; PMCA2; PMCA2a; PMCA2i;
抗原和靶标
Mainly expressed in brain cortex. Found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex and at low levels in other tissues. Isoforms containing segments X and W are found at low levels in all tissues. Isoforms containing segment A and segment Z are found at low levels in skeletal muscle and heart muscle.
- Q01814 AT2B2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVVKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKGVKKGDGLQLPAADGAAASNAADSANASLVNGKMQDGNVDASQSKAKQQDGAAAMEMQPLKSAEGGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLPECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLEEDAALKQNSSPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q01814 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T5 | Phosphorylation | Uniprot | |
| S18 | Phosphorylation | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| S184 | Phosphorylation | Uniprot | |
| K301 | Acetylation | Uniprot | |
| S346 | Phosphorylation | Uniprot | |
| K383 | Ubiquitination | Uniprot | |
| K389 | Acetylation | Uniprot | |
| K389 | Ubiquitination | Uniprot | |
| T449 | Phosphorylation | Uniprot | |
| Y469 | Phosphorylation | Uniprot | |
| S470 | Phosphorylation | Uniprot | |
| K476 | Ubiquitination | Uniprot | |
| S498 | Phosphorylation | Uniprot | |
| S528 | Phosphorylation | Uniprot | |
| Y597 | Phosphorylation | Uniprot | |
| S604 | Phosphorylation | Uniprot | |
| T726 | Phosphorylation | Uniprot | |
| K770 | Ubiquitination | Uniprot | |
| K780 | Ubiquitination | Uniprot | |
| S792 | Phosphorylation | Uniprot | |
| T794 | Phosphorylation | Uniprot | |
| K796 | Ubiquitination | Uniprot | |
| T798 | Phosphorylation | Uniprot | |
| T818 | Phosphorylation | Uniprot | |
| T822 | Phosphorylation | Uniprot | |
| K829 | Ubiquitination | Uniprot | |
| Y940 | Phosphorylation | Uniprot | |
| K944 | Ubiquitination | Uniprot | |
| R1097 | Methylation | Uniprot | |
| T1139 | Phosphorylation | Uniprot | |
| S1149 | Phosphorylation | Uniprot | |
| S1150 | Phosphorylation | Uniprot | |
| Y1152 | Phosphorylation | Uniprot | |
| K1157 | Ubiquitination | Uniprot | |
| S1160 | Phosphorylation | Uniprot | |
| T1162 | Phosphorylation | Uniprot | |
| S1178 | Phosphorylation | Uniprot | |
| S1211 | Phosphorylation | Uniprot | |
| S1229 | Phosphorylation | Uniprot | |
| S1230 | Phosphorylation | Uniprot | |
| S1231 | Phosphorylation | Uniprot | |
| S1234 | Phosphorylation | Uniprot | |
| S1238 | Phosphorylation | Uniprot | |
| T1241 | Phosphorylation | Uniprot | |
| S1242 | Phosphorylation | Uniprot |
研究背景
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
Cell junction>Synapse. Cell membrane>Multi-pass membrane protein.
Mainly expressed in brain cortex. Found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex and at low levels in other tissues. Isoforms containing segments X and W are found at low levels in all tissues. Isoforms containing segment A and segment Z are found at low levels in skeletal muscle and heart muscle.
Interacts with PDZD11.
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
研究领域
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.
· Organismal Systems > Digestive system > Salivary secretion.
· Organismal Systems > Digestive system > Pancreatic secretion.
文献引用
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