| 产品: | PLXNA2 抗体 |
| 货号: | DF9760 |
| 描述: | Rabbit polyclonal antibody to PLXNA2 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 211kDa; 211kD(Calculated). |
| 蛋白号: | O75051 |
| RRID: | AB_2842955 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9760, RRID:AB_2842955.
展开/折叠
Plexin-A2; PlexinA2; PLXA2; PLXA2_HUMAN; PLXNA2; Semaphorin receptor OCT;
抗原和靶标
- O75051 PLXA2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEQRRPWPRALEVDSRSVVLLSVVWVLLAPPAAGMPQFSTFHSENRDWTFNHLTVHQGTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKSCYPPLIVQPCSEVLTLTNNVNKLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPTLSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQPETPEGVAINSAGDLFYTSRIVRLCKDDPKFHSYVSLPFGCTRAGVEYRLLQAAYLAKPGDSLAQAFNITSQDDVLFAIFSKGQKQYHHPPDDSALCAFPIRAINLQIKERLQSCYQGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTPVEGLTLYTTSRDRMTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVLKDGSPILRDMAFSIDQRYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQQAWEPNRFAASISQCVSLAVHPSSISVSEHSRLLSLVVSDAPDLSAGIACAFGNLTEVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPTTCSFQEGRINISEDCPQLVPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECVLNIQGAIHRVPALRFNSSSVQCQNSSYQYDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKADRKFECGWCSGERRCTLHQHCTSPSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVPCTPLPGEYIIAEQIVCEMGHALVGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLSLNPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQTCEFYGRSMSEIVCVSPPSSNGLGPVPVSVSVDRAHVDSNLQFEYIDDPRVQRIEPEWSIASGHTPLTITGFNLDVIQEPRIRVKFNGKESVNVCKVVNTTTLTCLAPSLTTDYRPGLDTVERPDEFGFVFNNVQSLLIYNDTKFIYYPNPTFELLSPTGVLDQKPGSPIILKGKNLCPPASGGAKLNYTVLIGETPCAVTVSETQLLCEPPNLTGQHKVMVHVGGMVFSPGSVSVISDSLLTLPAIVSIAAGGSLLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSGIPYLDYRTYAMRVLFPGIEDHPVLRELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQRSFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLEWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASASISRTSISRYDSSFRYTGSPDSLRSRAPMITPDLESGVKVWHLVKNHDHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKSWVERYYADIAKLPAISDQDMNAYLAEQSRLHAVEFNMLSALNEIYSYVSKYSEELIGALEQDEQARRQRLAYKVEQLINAMSIES
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O75051 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Phosphorylation | Uniprot | ||
| S15 | Phosphorylation | Uniprot | |
| K138 | Acetylation | Uniprot | |
| K154 | Acetylation | Uniprot | |
| Y293 | Phosphorylation | Uniprot | |
| S295 | Phosphorylation | Uniprot | |
| S434 | Phosphorylation | Uniprot | |
| S444 | Phosphorylation | Uniprot | |
| Y470 | Phosphorylation | Uniprot | |
| S474 | Phosphorylation | Uniprot | |
| S850 | Phosphorylation | Uniprot | |
| S1264 | Phosphorylation | Uniprot | |
| K1272 | Ubiquitination | Uniprot | |
| S1388 | Phosphorylation | Uniprot | |
| K1424 | Ubiquitination | Uniprot | |
| K1451 | Acetylation | Uniprot | |
| K1489 | Ubiquitination | Uniprot | |
| T1524 | Phosphorylation | Uniprot | |
| Y1605 | Phosphorylation | Uniprot | |
| S1612 | Phosphorylation | Uniprot | |
| Y1627 | Phosphorylation | Uniprot | |
| T1628 | Phosphorylation | Uniprot | |
| S1630 | Phosphorylation | Uniprot | |
| S1633 | Phosphorylation | Uniprot | |
| S1636 | Phosphorylation | Uniprot | |
| S1670 | Phosphorylation | Uniprot | |
| Y1677 | Phosphorylation | Uniprot | |
| K1685 | Ubiquitination | Uniprot | |
| K1791 | Ubiquitination | Uniprot | |
| K1797 | Ubiquitination | Uniprot | |
| Y1800 | Phosphorylation | Uniprot | |
| S1806 | Phosphorylation | Uniprot | |
| Y1807 | Phosphorylation | Uniprot | |
| Y1814 | Phosphorylation | Uniprot | |
| Y1815 | Phosphorylation | Uniprot | |
| S1825 | Phosphorylation | Uniprot | |
| Y1860 | Phosphorylation | Uniprot | |
| S1861 | Phosphorylation | Uniprot |
研究背景
Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
Cell membrane>Single-pass type I membrane protein.
Detected in fetal brain.
Homodimer. The PLXNA2 homodimer interacts with a SEMA6A homodimer, giving rise to a heterotetramer. Interacts directly with NRP1 and NRP2 (By similarity). Interacts with RND1.
Belongs to the plexin family.
研究领域
· Organismal Systems > Development > Axon guidance. (View pathway)
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