PABPC4 Antibody - #DF9762

(4)  
产品: PABPC4 抗体
货号: DF9762
描述: Rabbit polyclonal antibody to PABPC4
应用: WB IHC IP
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
分子量: 71 kDa; 71kD(Calculated).
蛋白号: Q13310
RRID: AB_2842957

浏览相似产品>>

   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

联系销售
相关下载
MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Zebrafish(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%)
克隆:
Polyclonal
特异性:
PABPC4 Antibody detects endogenous levels of total PABPC4.
RRID:
AB_2842957
引用格式: Affinity Biosciences Cat# DF9762, RRID:AB_2842957.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Activated platelet protein 1; Activated-platelet protein 1; APP 1; APP-1; APP1; FLJ43938; Inducible poly(A) binding protein; Inducible poly(A)-binding protein; iPABP; IPABP4; PABP 4; PABP-4; PABP4; PABP4_HUMAN; PABPC 4; PABPC4; Poly A binding protein cytoplasmic 4; Poly(A) binding protein 4; Poly(A) binding protein cytoplasmic 4 (inducible form); Poly(A) binding protein cytoplasmic 4; Poly(A)-binding protein 4; Polyadenylate binding protein 4; Polyadenylate-binding protein 4; Polyadenylate-binding protein, cytoplasmic, 4; Polyadenylate-binding protein, inducible;

抗原和靶标

免疫原:
Uniprot:

Q13310(PABP4_HUMAN) >>Visit HPA database.

基因/基因ID:
PABPC4(8761)
表达:
Q13310 PABP4_HUMAN:

Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated.

序列:
MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAADKAIEKMNGMLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMRDPNGKSKGFGFVSYEKHEDANKAVEEMNGKEISGKIIFVGRAQKKVERQAELKRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKGFGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRALPANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMPSAIRQSGPRPTLRHLAPTGSECPDRLAMDFGGAGAAQQGLTDSCQSGGVPTAVQNLAPRAAVAAAAPRAVAPYKYASSVRSPHPAIQPLQAPQPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLIQTMHSNLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHHAKKEAAQKVGAVAAATS

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Zebrafish
100
Chicken
100
Rabbit
100
Xenopus
75
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q13310 作为底物

Site PTM Type Enzyme
S32 Phosphorylation
S39 Phosphorylation
S51 Phosphorylation
Y54 Phosphorylation
Y56 Phosphorylation
T71 Phosphorylation
K78 Ubiquitination
K80 Ubiquitination
S92 Phosphorylation
K95 Ubiquitination
S96 Phosphorylation
K104 Acetylation
K104 Ubiquitination
K108 Acetylation
K108 Ubiquitination
K113 Ubiquitination
Y116 Phosphorylation
S120 Phosphorylation
S127 Phosphorylation
K129 Ubiquitination
K138 Ubiquitination
Y140 Phosphorylation
K157 Ubiquitination
R166 Methylation
K167 Sumoylation
K167 Ubiquitination
K177 Ubiquitination
R179 Methylation
K186 Ubiquitination
K188 Methylation
K188 Ubiquitination
T191 Phosphorylation
Y194 Phosphorylation
K196 Ubiquitination
S206 Phosphorylation
K208 Ubiquitination
K216 Ubiquitination
K221 Ubiquitination
K240 Ubiquitination
K254 Ubiquitination
S257 Phosphorylation
K259 Ubiquitination
K279 Ubiquitination
K284 Ubiquitination
Y291 Phosphorylation
Y297 Phosphorylation
K299 Acetylation
K299 Ubiquitination
T304 Phosphorylation
K309 Ubiquitination
K312 Ubiquitination
S315 Phosphorylation
S319 Phosphorylation
T321 Phosphorylation
S322 Phosphorylation
K324 Ubiquitination
K333 Ubiquitination
S341 Phosphorylation
S342 Phosphorylation
K348 Ubiquitination
S360 Phosphorylation
K361 Ubiquitination
Y364 Phosphorylation
K375 Methylation
K375 Ubiquitination
T379 Phosphorylation
Y382 Phosphorylation
R385 Methylation
R419 Methylation
R432 Methylation
R436 Methylation
R442 Methylation
R454 Methylation
R459 Methylation
R463 Methylation
R509 Methylation
R518 Methylation
K524 Methylation
R530 Methylation
S531 Phosphorylation
S584 Phosphorylation
S600 Phosphorylation
S608 Phosphorylation
K629 Ubiquitination
K635 Ubiquitination
S644 Phosphorylation

研究背景

功能:

Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).

翻译修饰:

Arg-518 is dimethylated, probably to asymmetric dimethylarginine.

细胞定位:

Cytoplasm.
Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated.

亚基结构:

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with NFX1. Interacts with ZFC3H1 in a RNase-sensitive manner.

蛋白家族:

Belongs to the polyadenylate-binding protein type-1 family.

研究领域

· Genetic Information Processing > Translation > RNA transport.

· Genetic Information Processing > Translation > mRNA surveillance pathway.

· Genetic Information Processing > Folding, sorting and degradation > RNA degradation.

限制条款

产品的规格、报价、验证数据请以官网为准，官网链接：www.affbiotech.com | www.affbiotech.cn（简体中文）| www.affbiotech.jp（日本語）

产品的数据信息为Affinity所有，未经授权不得收集Affinity官网数据或资料用于商业用途，对抄袭产品数据的行为我们将保留诉诸法律的权利。

产品相关数据会因产品批次、产品检测情况随时调整，如您已订购该产品，请以订购时随货说明书为准，否则请以官网内容为准，官网内容有改动时恕不另行通知。

Affinity保证所销售产品均经过严格质量检测。如您购买的商品在规定时间内出现问题需要售后时，请您在Affinity官方渠道提交售后申请。

产品仅供科学研究使用。不用于诊断和治疗。 

产品未经授权不得转售。

Affinity Biosciences将不会对在使用我们的产品时可能发生的专利侵权或其他侵权行为负责。Affinity Biosciences, Affinity Biosciences标志和所有其他商标所有权归Affinity Biosciences LTD.