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| 产品: | HCN4 抗体 |
| 货号: | DF9771 |
| 描述: | Rabbit polyclonal antibody to HCN4 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat, Monkey |
| 预测: | Pig, Bovine, Rabbit |
| 分子量: | 129 kDa; 129kD(Calculated). |
| 蛋白号: | Q9Y3Q4 |
| RRID: | AB_2842966 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9771, RRID:AB_2842966.
展开/折叠
HCN 4; Hyperpolarization activated cyclic nucleotide gated potassium channel 4; Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 4;
抗原和靶标
Highly expressed in thalamus, testis and in heart, both in ventricle and atrium. Detected at much lower levels in amygdala, substantia nigra, cerebellum and hippocampus.
- Q9Y3Q4 HCN4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDAEEEGAGGRQDPSRRSIRLRPLPSPSPSAAAGGTESRSSALGAADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGGSGGTGSGSSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCEQPSVDTAIKVEGGAAAGDQILPEAEVRLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVAATTIAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREPGARPEPVRSKLPSNL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9Y3Q4 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S14 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S67 | Phosphorylation | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| S99 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S110 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S117 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S230 | Phosphorylation | Uniprot | |
| S236 | Phosphorylation | Uniprot | |
| Y531 | Phosphorylation | P12931 (SRC) | Uniprot |
| Y554 | Phosphorylation | Uniprot | |
| T650 | Phosphorylation | Uniprot | |
| S719 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S831 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S917 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S921 | Phosphorylation | Uniprot | |
| S1005 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S1011 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S1015 | Phosphorylation | Uniprot | |
| T1020 | Phosphorylation | Uniprot | |
| S1026 | Phosphorylation | Uniprot | |
| S1051 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| T1071 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| T1075 | Phosphorylation | Uniprot | |
| S1112 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S1131 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| T1156 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S1157 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S1158 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S1160 | Phosphorylation | P17612 (PRKACA) | Uniprot |
研究背景
Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli.
Cell membrane>Multi-pass membrane protein.
Highly expressed in thalamus, testis and in heart, both in ventricle and atrium. Detected at much lower levels in amygdala, substantia nigra, cerebellum and hippocampus.
Homotetramer. The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Belongs to the potassium channel HCN family.
研究领域
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Organismal Systems > Sensory system > Taste transduction.
文献引用
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