产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9786, RRID:AB_2842981.
展开/折叠
Protein translocation complex beta; Protein transport protein SEC61 beta subunit; Protein transport protein Sec61 subunit beta; SC61B_HUMAN; SEC 61B; SEC61 B; Sec61 beta subunit; Sec61 complex beta subunit; SEC61B;
抗原和靶标
- P60468 SC61B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPGPTPSGTNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSAGRTTSAGTGGMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P60468 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| P2 | Acetylation | Uniprot | |
| T5 | Phosphorylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| T9 | Phosphorylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| K20 | Ubiquitination | Uniprot | |
| S29 | Phosphorylation | Uniprot | |
| T30 | Phosphorylation | Uniprot | |
| S38 | Phosphorylation | Uniprot | |
| S43 | Phosphorylation | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| T52 | Phosphorylation | Uniprot | |
| T60 | Phosphorylation | Uniprot | |
| S63 | Phosphorylation | Uniprot |
研究背景
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER) (By similarity). Required for PKD1/Polycystin-1 biogenesis (By similarity).
Endoplasmic reticulum membrane>Single-pass membrane protein.
The ER translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63.
Belongs to the SEC61-beta family.
研究领域
· Cellular Processes > Transport and catabolism > Phagosome. (View pathway)
· Genetic Information Processing > Folding, sorting and degradation > Protein export.
· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Vibrio cholerae infection.
限制条款
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