| 产品: | SEPT5 抗体 |
| 货号: | DF9881 |
| 描述: | Rabbit polyclonal antibody to SEPT5 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Dog, Chicken, Xenopus |
| 分子量: | 43 kDa; 43kD(Calculated). |
| 蛋白号: | Q99719 |
| RRID: | AB_2843075 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9881, RRID:AB_2843075.
展开/折叠
5 Sep; CDCrel 1; CDCREL; CDCrel-1; CDCREL1; Cell division control related protein 1; Cell division control-related protein 1; H5; HCDCREL 1; OTTHUMP00000197271; OTTHUMP00000197272; OTTHUMP00000197273; OTTHUMP00000197274; OTTHUMP00000197275; OTTHUMP00000197276; OTTHUMP00000197396; OTTHUMP00000197410; Peanut like 1; Peanut like 1 homolog; Peanut like protein 1; Peanut-like protein 1; Platelet glycoprotein Ib beta chain; PNUTL1; SEPT5; SEPT5_HUMAN; Septin 5; Septin-5;
抗原和靶标
Expressed at high levels in the CNS, as well as in heart and platelets (at protein level).
- Q99719 SEPT5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSTGLRYKSKLATPEDKQDIDKQYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVHSLFLTDLYKDRKLLSAEERISQTVEILKHTVDIEEKGVKLKLTIVDTPGFGDAVNNTECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPVDVGFMKALHEKVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPECDSDEDEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKLRNMLIRTHMHDLKDVTCDVHYENYRAHCIQQMTSKLTQDSRMESPIPILPLPTPDAETEKLIRMKDEELRRMQEMLQRMKQQMQDQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q99719 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R6 | Methylation | Uniprot | |
| T13 | Phosphorylation | Uniprot | |
| Y24 | Phosphorylation | Uniprot | |
| T29 | Phosphorylation | Uniprot | |
| K41 | Ubiquitination | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| S225 | Phosphorylation | Uniprot | |
| S249 | Phosphorylation | Uniprot | |
| T251 | Phosphorylation | Uniprot | |
| K318 | Ubiquitination | Uniprot | |
| S327 | Phosphorylation | Uniprot | |
| T336 | Phosphorylation | Uniprot | |
| T341 | Phosphorylation | Uniprot | |
| K343 | Ubiquitination | Uniprot | |
| K363 | Methylation | Uniprot |
研究背景
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity).
In platelets, phosphorylated in response to thrombin, phorbol-12-myristate-13-acetate and collagen.
Cytoplasm. Cytoplasm>Cytoskeleton.
Note: In platelets, found in areas surrounding alpha-granules.
Expressed at high levels in the CNS, as well as in heart and platelets (at protein level).
Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with SEPTIN2 and SEPTIN5. In platelets, associated with a complex containing STX4. Interacts with PRKN. This interaction leads to SEPTIN5 ubiquitination and degradation (By similarity).
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
研究领域
· Human Diseases > Neurodegenerative diseases > Parkinson's disease.
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