产品: SERPINB10 抗体
货号: DF9894
描述: Rabbit polyclonal antibody to SERPINB10
应用: WB
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Horse, Rabbit, Dog
分子量: 45 kDa; 45kD(Calculated).
蛋白号: P48595
RRID: AB_2843088

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 50ul RMB¥ 1600 现货
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产品描述

来源:
Rabbit
应用:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(91%), Horse(91%), Rabbit(91%), Dog(82%)
克隆:
Polyclonal
特异性:
SERPINB10 Antibody detects endogenous levels of total SERPINB10.
RRID:
AB_2843088
引用格式: Affinity Biosciences Cat# DF9894, RRID:AB_2843088.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Bomapin; Peptidase inhibitor 10; PI-10; PI10; Protease inhibitor 10; Protease inhibitor 10 (ovalbumin type bomapin); Serpin B10; Serpin peptidase inhibitor clade B (ovalbumin) member 10; SERPINB10; SPB10_HUMAN;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
P48595 SPB10_HUMAN:

Expressed specifically in myeloid cells and the bone marrow.

序列:
MDSLATSINQFALELSKKLAESAQGKNIFFSSWSISTSLTIVYLGAKGTTAAQMAQVLQFNRDQGVKCDPESEKKRKMEFNLSNSEEIHSDFQTLISEILKPNDDYLLKTANAIYGEKTYAFHNKYLEDMKTYFGAEPQPVNFVEASDQIRKDINSWVERQTEGKIQNLLPDDSVDSTTRMILVNALYFKGIWEHQFLVQNTTEKPFRINETTSKPVQMMFMKKKLHIFHIEKPKAVGLQLYYKSRDLSLLILLPEDINGLEQLEKAITYEKLNEWTSADMMELYEVQLHLPKFKLEDSYDLKSTLSSMGMSDAFSQSKADFSGMSSARNLFLSNVFHKAFVEINEQGTEAAAGSGSEIDIRIRVPSIEFNANHPFLFFIRHNKTNTILFYGRLCSP

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Pig
91
Horse
91
Rabbit
91
Dog
82
Bovine
73
Sheep
73
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P48595 作为底物

Site PTM Type Enzyme
S307 Phosphorylation
S318 Phosphorylation

研究背景

功能:

Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus.

细胞定位:

Nucleus. Cytoplasm.
Note: Mostly found in the nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed specifically in myeloid cells and the bone marrow.

蛋白家族:

Belongs to the serpin family. Ov-serpin subfamily.

研究领域

· Human Diseases > Infectious diseases: Parasitic > Amoebiasis.

文献引用

1). Non-Esterified Fatty Acid-Induced Apoptosis in Bovine Granulosa Cells via ROS-Activated PI3K/AKT/FoxO1 Pathway. Antioxidants, 2023 (PubMed: 36829992) [IF=7.0]

2). Proteomic analyses reveal higher levels of neutrophil activation in men than in women with systemic lupus erythematosus. Frontiers in Immunology, 2022 (PubMed: 35799787) [IF=5.7]

Application: WB    Species: Human    Sample:

Figure 6 Western Blot Validation of Proteins in Neutrophil Activation Networks. (A) Western blot analysis of BST2, PGAM1 and SERPINB10 in male SLE and female SLE. (B) Boxplot showing gray value of BST2 in male SLE and female SLE. (C) Boxplot showing gray value of PGAM1 in male SLE and female SLE. (D) Boxplot showing gray value of SERPINB10 in male SLE and female SLE.

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