| 产品: | SerpinB6 抗体 |
| 货号: | DF9895 |
| 描述: | Rabbit polyclonal antibody to SerpinB6 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Dog |
| 分子量: | 43 kDa; 43kD(Calculated). |
| 蛋白号: | P35237 |
| RRID: | AB_2843089 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9895, RRID:AB_2843089.
展开/折叠
CAP; Cytoplasmic antiproteinase; Peptidase inhibitor 6; PI-6; PI6; Placental thrombin inhibitor; Protease inhibitor 6 (placental thrombin inhibitor); PTI; Serpin B6; SERPINB6; SPB6_HUMAN;
抗原和靶标
Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions.
- P35237 SPB6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDVLAEANGTFALNLLKTLGKDNSKNVFFSPMSMSCALAMVYMGAKGNTAAQMAQILSFNKSGGGGDIHQGFQSLLTEVNKTGTQYLLRMANRLFGEKSCDFLSSFRDSCQKFYQAEMEELDFISAVEKSRKHINTWVAEKTEGKIAELLSPGSVDPLTRLVLVNAVYFRGNWDEQFDKENTEERLFKVSKNEEKPVQMMFKQSTFKKTYIGEIFTQILVLPYVGKELNMIIMLPDETTDLRTVEKELTYEKFVEWTRLDMMDEEEVEVSLPRFKLEESYDMESVLRNLGMTDAFELGKADFSGMSQTDLSLSKVVHKSFVEVNEEGTEAAAATAAIMMMRCARFVPRFCADHPFLFFIQHSKTNGILFCGRFSSP
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P35237 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| Y42 | Phosphorylation | Uniprot | |
| T49 | Phosphorylation | Uniprot | |
| S58 | Phosphorylation | Uniprot | |
| K61 | Ubiquitination | Uniprot | |
| S62 | Phosphorylation | Uniprot | |
| R89 | Methylation | Uniprot | |
| R93 | Methylation | Uniprot | |
| S99 | Phosphorylation | Uniprot | |
| K129 | Ubiquitination | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| S151 | Phosphorylation | Uniprot | |
| Y168 | Phosphorylation | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| T182 | Phosphorylation | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| K246 | Ubiquitination | Uniprot | |
| Y250 | Phosphorylation | Uniprot | |
| K252 | Acetylation | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| K314 | Ubiquitination | Uniprot |
研究背景
May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
Cytoplasm.
Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions.
Forms a complex with the monomeric form of beta-tryptase.
Belongs to the serpin family. Ov-serpin subfamily.
研究领域
· Human Diseases > Infectious diseases: Parasitic > Amoebiasis.
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