SH2B3 Antibody - #DF9898

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产品: SH2B3 抗体
货号: DF9898
描述: Rabbit polyclonal antibody to SH2B3
应用: WB IHC IF/ICC
反应: Human
分子量: 63 kDa, 80 kDa; 63kD(Calculated).
蛋白号: Q9UQQ2
RRID: AB_2843092

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
克隆:
Polyclonal
特异性:
SH2B3 Antibody detects endogenous levels of total SH2B3.
RRID:
AB_2843092
引用格式: Affinity Biosciences Cat# DF9898, RRID:AB_2843092.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

IDDM20; Lymphocyte adapter protein; Lymphocyte specific adapter protein; Lymphocyte specific adapter protein Lnk; Lymphocyte-specific adapter protein Lnk; SH2B adapter protein 3; SH2B adaptor protein 3; Sh2b3; SH2B3_HUMAN; Signal transduction protein Lnk;

抗原和靶标

免疫原:
Uniprot:

Q9UQQ2(SH2B3_HUMAN) >>Visit HPA database.

基因/基因ID:
SH2B3(10019)
表达:
Q9UQQ2 SH2B3_HUMAN:

Preferentially expressed by lymphoid cell lines.

序列:
MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAKKFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL

翻译修饰 - Q9UQQ2 作为底物

Site PTM Type Enzyme
S10 Phosphorylation
S16 Phosphorylation
S18 Phosphorylation
K99 Ubiquitination
S103 Phosphorylation
S120 Phosphorylation
S150 Phosphorylation
T159 Phosphorylation
T165 Phosphorylation
Y203 Phosphorylation
Y273 Phosphorylation P43403 (ZAP70) , P06239 (LCK)
S330 Phosphorylation
S337 Phosphorylation
S343 Phosphorylation
K373 Ubiquitination
S511 Phosphorylation
S553 Phosphorylation
Y555 Phosphorylation
S559 Phosphorylation
S560 Phosphorylation
Y572 Phosphorylation

研究背景

功能:

Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.

翻译修饰:

Tyrosine phosphorylated by LCK.

组织特异性:

Preferentially expressed by lymphoid cell lines.

亚基结构:

Binds to the tyrosine-phosphorylated TCR zeta chain via its SH2 domain.

蛋白家族:

Belongs to the SH2B adapter family.

研究领域

· Organismal Systems > Nervous system > Neurotrophin signaling pathway.   (View pathway)

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