| 产品: | SCN1B 抗体 |
| 货号: | DF9930 |
| 描述: | Rabbit polyclonal antibody to SCN1B |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 25 kDa; 25kD(Calculated). |
| 蛋白号: | Q07699 |
| RRID: | AB_2843124 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9930, RRID:AB_2843124.
展开/折叠
GEFSP1; SCN1B; SCN1B_HUMAN; sodium channel beta 1 subunit; Sodium channel subunit beta 1; Sodium channel subunit beta-1; Sodium channel voltage gated type I beta; Sodium channel voltage gated type I beta subunit;
抗原和靶标
The overall expression of isoform 1 and isoform 2 is very similar. Isoform 1 is abundantly expressed in skeletal muscle, heart and brain. Isoform 2 is highly expressed in brain and skeletal muscle and present at a very low level in heart, placenta, lung, liver, kidney and pancreas. In brain, isoform 2 is most abundant in the cerebellum, followed by the cerebral cortex and occipital lobe, while isoform 1 levels are higher in the cortex compared to the cerebellum. Isoform 2 is expressed in many regions of the brain, including cerebellar Purkinje cells, cortex pyramidal neurons and many of the neuronal fibers throughout the brain (at protein level). Also detected in dorsal root ganglion, in fibers of the spinal nerve and in cortical neurons and their processes (at protein level).
- Q07699 SCN1B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIYCYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q07699 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N110 | N-Glycosylation | Uniprot | |
| N114 | N-Glycosylation | Uniprot |
研究背景
Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of multiple pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A.
Cell adhesion molecule that plays a critical role in neuronal migration and pathfinding during brain development. Stimulates neurite outgrowth. Has no regulatory function on the SCN2A sodium channel complex.
Cell membrane>Single-pass type I membrane protein. Perikaryon. Cell projection. Cell projection>Axon.
Note: Detected at nodes of Ranvier on the sciatic nerve.
Perikaryon. Cell projection. Secreted.
Note: Detected on Purkinje cells and their cell projections and on neuronal cell projections.
The overall expression of isoform 1 and isoform 2 is very similar. Isoform 1 is abundantly expressed in skeletal muscle, heart and brain. Isoform 2 is highly expressed in brain and skeletal muscle and present at a very low level in heart, placenta, lung, liver, kidney and pancreas. In brain, isoform 2 is most abundant in the cerebellum, followed by the cerebral cortex and occipital lobe, while isoform 1 levels are higher in the cortex compared to the cerebellum. Isoform 2 is expressed in many regions of the brain, including cerebellar Purkinje cells, cortex pyramidal neurons and many of the neuronal fibers throughout the brain (at protein level). Also detected in dorsal root ganglion, in fibers of the spinal nerve and in cortical neurons and their processes (at protein level).
Component of a voltage-sensitive sodium channel complex that consists of a pore-forming alpha subunit and one or more regulatory beta subunits. Interacts with SCN4A. Interacts with NFASC. Interacts with SCN10A (By similarity). Interacts with SCN1A. Interacts with SCN3A. Interacts with SCN5A. Interacts with SCN8A.
Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
研究领域
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
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