产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9963, RRID:AB_2843157.
展开/折叠
ALS2CR 3; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 3; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein; CALS C; GRIF 1; GRIF1; KIAA0549; OIP98; Trafficking kinesin-binding protein 2; Trafficking protein kinesin binding 2; Trak2; TRAK2_HUMAN;
抗原和靶标
- O60296 TRAK2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSQSQNAIFTSPTGEENLMNSNHRDSESITDVCSNEDLPEVELVSLLEEQLPQYRLKVDTLFLYENQDWTQSPHQRQHASDALSPVLAEETFRYMILGTDRVEQMTKTYNDIDMVTHLLAERDRDLELAARIGQALLKRNHVLSEQNESLEEQLGQAFDQVNQLQHELCKKDELLRIVSIASEESETDSSCSTPLRFNESFSLSQGLLQLEMLQEKLKELEEENMALRSKACHIKTETVTYEEKEQQLVSDCVKELRETNAQMSRMTEELSGKSDELIRYQEELSSLLSQIVDLQHKLKEHVIEKEELKLHLQASKDAQRQLTMELHELQDRNMECLGMLHESQEEIKELRSRSGPTAHLYFSQSYGAFTGESLAAEIEGTMRKKLSLDEESSLFKQKAQQKRVFDTVRIANDTRGRSISFPALLPIPGSNRSSVIMTAKPFESGLQQTEDKSLLNQGSSSEEVAGSSQKMGQPGPSGDSDLATALHRLSLRRQNYLSEKQFFAEEWQRKIQVLADQKEGVSGCVTPTESLASLCTTQSEITDLSSASCLRGFMPEKLQIVKPLEGSQTLYHWQQLAQPNLGTILDPRPGVITKGFTQLPGDAIYHISDLEEDEEEGITFQVQQPLEVEEKLSTSKPVTGIFLPPITSAGGPVTVATANPGKCLSCTNSTFTFTTCRILHPSDITQVTPSSGFPSLSCGSSGSSSSNTAVNSPALSYRLSIGESITNRRDSTTTFSSTMSLAKLLQERGISAKVYHSPISENPLQPLPKSLAIPSTPPNSPSHSPCPSPLPFEPRVHLSENFLASRPAETFLQEMYGLRPSRNPPDVGQLKMNLVDRLKRLGIARVVKNPGAQENGRCQEAEIGPQKPDSAVYLNSGSSLLGGLRRNQSLPVIMGSFAAPVCTSSPKMGVLKED
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O60296 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S84 | Phosphorylation | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| K138 | Ubiquitination | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| Y280 | Phosphorylation | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| S289 | Phosphorylation | Uniprot | |
| K299 | Acetylation | Uniprot | |
| K299 | Ubiquitination | Uniprot | |
| K316 | Ubiquitination | Uniprot | |
| K385 | Ubiquitination | Uniprot | |
| S387 | Phosphorylation | Uniprot | |
| K396 | Ubiquitination | Uniprot | |
| S420 | Phosphorylation | Uniprot | |
| S430 | Phosphorylation | Uniprot | |
| S498 | Phosphorylation | Uniprot | |
| K510 | Ubiquitination | Uniprot | |
| S567 | Phosphorylation | Uniprot | |
| T674 | Phosphorylation | Uniprot | |
| T675 | Phosphorylation | Uniprot | |
| T688 | Phosphorylation | Uniprot | |
| S691 | Phosphorylation | Uniprot | |
| T708 | Phosphorylation | Uniprot | |
| S731 | Phosphorylation | Uniprot | |
| S751 | Phosphorylation | Uniprot | |
| S760 | Phosphorylation | Uniprot | |
| S775 | Phosphorylation | Uniprot | |
| T776 | Phosphorylation | Uniprot | |
| S780 | Phosphorylation | Uniprot | |
| S782 | Phosphorylation | Uniprot | |
| S784 | Phosphorylation | Uniprot | |
| S788 | Phosphorylation | Uniprot | |
| T810 | Phosphorylation | Uniprot | |
| Y816 | Phosphorylation | Uniprot | |
| K831 | Methylation | Uniprot | |
| S889 | Phosphorylation | Uniprot |
研究背景
May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.
O-glycosylated.
Cytoplasm. Early endosome. Mitochondrion.
Note: Colocalizes with MGARP at the mitochondria. Translocates from the cytoplasm to the mitochondria in a MGARP-dependent manner (By similarity).
Widely expressed, with highest expression in heart.
Interacts with GABA-A receptor and O-GlcNAc transferase. Interacts with HGS (By similarity). Interacts with RHOT1/Miro-1 and RHOT2/Miro-2.
Belongs to the milton family.
研究领域
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Nervous system > GABAergic synapse.
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