| 产品: | CNOT2 抗体 |
| 货号: | AF9043 |
| 描述: | Rabbit polyclonal antibody to CNOT2 |
| 应用: | WB |
| 反应: | Human |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 46kDa; 60kD(Calculated). |
| 蛋白号: | Q9NZN8 |
| RRID: | AB_2843234 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF9043, RRID:AB_2843234.
展开/折叠
CCR4 associated factor 2; CCR4 NOT transcription complex subunit 2; CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CDC36; CNOT2; CNOT2_HUMAN; HSPC131; MSTP046; Negative regulator of transcription 2; NOT2 (negative regulator of transcription 2 yeast) homolog; NOT2; NOT2H;
抗原和靶标
Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.
- Q9NZN8 CNOT2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQFGASLYGQQSALGLPMRGMSNNTPQLNRSLSQGTQLPSHVTPTTGVPTMSLHTPPSPSRGILPMNPRNMMNHSQVGQGIGIPSRTNSMSSSGLGSPNRSSPSIICMPKQQPSRQPFTVNSMSGFGMNRNQAFGMNNSLSSNIFNGTDGSENVTGLDLSDFPALADRNRREGSGNPTPLINPLAGRAPYVGMVTKPANEQSQDFSIHNEDFPALPGSSYKDPTSSNDDSKSNLNTSGKTTSSTDGPKFPGDKSSTTQNNNQQKKGIQVLPDGRVTNIPQGMVTDQFGMIGLLTFIRAAETDPGMVHLALGSDLTTLGLNLNSPENLYPKFASPWASSPCRPQDIDFHVPSEYLTNIHIRDKLAAIKLGRYGEDLLFYLYYMNGGDVLQLLAAVELFNRDWRYHKEERVWITRAPGMEPTMKTNTYERGTYYFFDCLNWRKVAKEFHLEYDKLEERPHLPSTFNYNPAQQAF
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9NZN8 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K12 | Ubiquitination | Uniprot | |
| S35 | Phosphorylation | Uniprot | |
| Y37 | Phosphorylation | Uniprot | |
| Y43 | Phosphorylation | Uniprot | |
| Y44 | Phosphorylation | Uniprot | |
| S45 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| S48 | Phosphorylation | Uniprot | |
| K56 | Acetylation | Uniprot | |
| S61 | Phosphorylation | Uniprot | |
| S63 | Phosphorylation | Uniprot | |
| S65 | Phosphorylation | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| R87 | Methylation | Uniprot | |
| S90 | Phosphorylation | Uniprot | |
| T93 | Phosphorylation | Uniprot | |
| S99 | Phosphorylation | Uniprot | |
| S101 | Phosphorylation | Q13535 (ATR) | Uniprot |
| T104 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| T111 | Phosphorylation | Uniprot | |
| T113 | Phosphorylation | Uniprot | |
| T114 | Phosphorylation | Uniprot | |
| T118 | Phosphorylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| T123 | Phosphorylation | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| R137 | Methylation | Uniprot | |
| S143 | Phosphorylation | Uniprot | |
| T155 | Phosphorylation | Uniprot | |
| S157 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| S160 | Phosphorylation | Uniprot | |
| S161 | Phosphorylation | Uniprot | |
| S165 | Phosphorylation | Uniprot | |
| S169 | Phosphorylation | Uniprot | |
| S170 | Phosphorylation | Uniprot | |
| S242 | Phosphorylation | Uniprot | |
| T246 | Phosphorylation | Uniprot | |
| Y258 | Phosphorylation | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| S293 | Phosphorylation | Uniprot | |
| S294 | Phosphorylation | Uniprot | |
| K299 | Acetylation | Uniprot | |
| T304 | Phosphorylation | Uniprot | |
| S305 | Phosphorylation | Uniprot | |
| K307 | Ubiquitination | Uniprot | |
| T308 | Phosphorylation | Uniprot | |
| K321 | Ubiquitination | Uniprot | |
| S391 | Phosphorylation | Uniprot | |
| Y396 | Phosphorylation | Uniprot | |
| Y471 | Phosphorylation | Uniprot | |
| T480 | Phosphorylation | Uniprot | |
| K490 | Ubiquitination | Uniprot | |
| Y494 | Phosphorylation | Uniprot | |
| Y500 | Phosphorylation | Uniprot | |
| K512 | Ubiquitination | Uniprot | |
| K520 | Ubiquitination | Uniprot |
研究背景
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity.
Cytoplasm. Nucleus.
Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.
Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT3. Interacts with NCOR1, NCOR2. HDAC3 and GPS2.
Belongs to the CNOT2/3/5 family.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > RNA degradation.
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