| 产品: | DNA pol lambda 抗体 |
| 货号: | AF9055 |
| 描述: | Rabbit polyclonal antibody to DNA pol lambda |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 63kDa; 63kD(Calculated). |
| 蛋白号: | Q9UGP5 |
| RRID: | AB_2843246 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF9055, RRID:AB_2843246.
展开/折叠
BETA N; BETAN; DNA directed DNA polymerase lambda; DNA polymerase beta 2; DNA polymerase beta-2; DNA polymerase kappa; DNA polymerase kappa DNA polymerase beta N; DNA polymerase lambda; DNA polymerase lamda2; DPOLL_HUMAN; EC 2.7.7.7,EC 4.2.99.; FLJ46002; OTTHUMP00000020321; OTTHUMP00000020323; OTTHUMP00000059179; Pol beta2; POL KAPPA; Pol Lambda; POLKAPPA; POLL; Polymerase DNA directed lambda;
抗原和靶标
- Q9UGP5 DPOLL_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDPRGILKAFPKRQKIHADASSKVLAKIPRREEGEEAEEWLSSLRAHVVRTGIGRARAELFEKQIVQHGGQLCPAQGPGVTHIVVDEGMDYERALRLLRLPQLPPGAQLVKSAWLSLCLQERRLVDVAGFSIFIPSRYLDHPQPSKAEQDASIPPGTHEALLQTALSPPPPPTRPVSPPQKAKEAPNTQAQPISDDEASDGEETQVSAADLEALISGHYPTSLEGDCEPSPAPAVLDKWVCAQPSSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9UGP5 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K23 | Ubiquitination | Uniprot | |
| K27 | Ubiquitination | Uniprot | |
| S43 | Phosphorylation | Uniprot | |
| S167 | Phosphorylation | P24941 (CDK2) | Uniprot |
| T173 | Phosphorylation | Uniprot | |
| S177 | Phosphorylation | P24941 (CDK2) | Uniprot |
| T204 | Phosphorylation | Uniprot | |
| S230 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S246 | Phosphorylation | Uniprot | |
| K248 | Ubiquitination | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| S359 | Phosphorylation | Uniprot | |
| Y380 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| T553 | Phosphorylation | P24941 (CDK2) | Uniprot |
研究背景
DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
Nucleus.
Expressed in a number of tissues. Abundant in testis.
Binds PCNA.
Belongs to the DNA polymerase type-X family.
研究领域
· Genetic Information Processing > Replication and repair > Base excision repair.
· Genetic Information Processing > Replication and repair > Non-homologous end-joining.
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