| 产品: | GS28 抗体 |
| 货号: | AF9082 |
| 描述: | Rabbit polyclonal antibody to GS28 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 37kDa; 29kD(Calculated). |
| 蛋白号: | O95249 |
| RRID: | AB_2843273 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF9082, RRID:AB_2843273.
展开/折叠
28 kDa cis Golgi SNARE p28; 28 kDa Golgi SNARE protein; cis-golgi SNARE; golgi integral membrane protein 2; Golgi SNAP receptor complex member 1; Golgi SNARE 28 kDa; GOLIM2; GOS28; GOS28/P28; GOSR1; GS25; Gs28; P28;
抗原和靶标
- O95249 GOSR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAGTSSYWEDLRKQARQLENELDLKLVSFSKLCTSYSHSSTRDGRRDRYSSDTTPLLNGSSQDRMFETMAIEIEQLLARLTGVNDKMAEYTNSAGVPSLNAALMHTLQRHRDILQDYTHEFHKTKANFMAIRERENLMGSVRKDIESYKSGSGVNNRRTELFLKEHDHLRNSDRLIEETISIAMATKENMTSQRGMLKSIHSKMNTLANRFPAVNSLIQRINLRKRRDSLILGGVIGICTILLLLYAFH
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O95249 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K26 | Ubiquitination | Uniprot | |
| K32 | Ubiquitination | Uniprot | |
| S36 | Phosphorylation | Uniprot | |
| Y37 | Phosphorylation | Uniprot | |
| S38 | Phosphorylation | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| S52 | Phosphorylation | Uniprot | |
| K124 | Acetylation | Uniprot | |
| K124 | Ubiquitination | Uniprot | |
| S141 | Phosphorylation | Uniprot | |
| K144 | Ubiquitination | Uniprot | |
| S148 | Phosphorylation | Uniprot | |
| Y149 | Phosphorylation | Uniprot | |
| K150 | Methylation | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| T160 | Phosphorylation | Uniprot | |
| K165 | Ubiquitination | Uniprot | |
| K188 | Ubiquitination | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| K204 | Ubiquitination | Uniprot | |
| S217 | Phosphorylation | Uniprot |
研究背景
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
Golgi apparatus membrane>Single-pass type IV membrane protein.
Note: Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network (By similarity). Enriched on vesicular components at the terminal rims of the Golgi. Found in Golgi microtubules at low temperature (15 degrees Celsius).
Component of several multiprotein Golgi SNARE complexes. Identified in a SNARE complex with BET1, STX5 and YKT6, in a SNARE complex with BET1L, STX5 and YKT6, in a SNARE complex with STX5, GOSR2, SEC22B and BET1, and in complex with STX5 and COG3. Interacts with GABARAPL2 (By similarity).
Belongs to the GOSR1 family.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > SNARE interactions in vesicular transport.
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