| 产品: | InsP5 2-kinase 抗体 |
| 货号: | AF9097 |
| 描述: | Rabbit polyclonal antibody to InsP5 2-kinase |
| 应用: | WB IHC |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 56kDa; 56kD(Calculated). |
| 蛋白号: | Q9H8X2 |
| RRID: | AB_2843288 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF9097, RRID:AB_2843288.
展开/折叠
3; 4; 5; 6)P5 2-kinase; 6-pentakisphosphate 2-kinase; bA476B13.1 (novel protein); bA476B13.1; C9orf12; inositol 1,3,4,5,6 pentakisphosphate 2 kinase; Inositol pentakisphosphate 2 kinase; Inositol-1; Inositol-pentakisphosphate 2-kinase; Ins; Ins(1; Ins(1,3,4,5,6)P5 2 kinase; InsP5 2 kinase; InsP5 2-kinase; INSP5K2; IP5K; IPK1; IPK1 homolog; IPPK; IPPK_HUMAN;
抗原和靶标
Ubiquitously expressed, with high expression in heart, brain, testis and placenta.
- Q9H8X2 IPPK_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEEGKMDENEWGYHGEGNKSLVVAHAQRCVVLRFLKFPPNRKKTSEEIFQHLQNIVDFGKNVMKEFLGENYVHYGEVVQLPLEFVKQLCLKIQSERPESRCDKDLDTLSGYAMCLPNLTRLQTYRFAEHRPILCVEIKPKCGFIPFSSDVTHEMKHKVCRYCMHQHLKVATGKWKQISKYCPLDLYSGNKQRMHFALKSLLQEAQNNLKIFKNGELIYGCKDARSPVADWSELAHHLKPFFFPSNGLASGPHCTRAVIRELVHVITRVLLSGSDKGRAGTLSPGLGPQGPRVCEASPFSRSLRCQGKNTPERSGLPKGCLLYKTLQVQMLDLLDIEGLYPLYNRVERYLEEFPEERKTLQIDGPYDEAFYQKLLDLSTEDDGTVAFALTKVQQYRVAMTAKDCSIMIALSPCLQDASSDQRPVVPSSRSRFAFSVSVLDLDLKPYESIPHQYKLDGKIVNYYSKTVRAKDNAVMSTRFKESEDCTLVLHKV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9H8X2 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K173 | Ubiquitination | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| K190 | Ubiquitination | Uniprot | |
| K198 | Methylation | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| K317 | Ubiquitination | Uniprot | |
| K357 | Ubiquitination | Uniprot | |
| S404 | Phosphorylation | Uniprot | |
| S418 | Phosphorylation | Uniprot | |
| K457 | Ubiquitination | Uniprot | |
| K479 | Ubiquitination | Uniprot | |
| K490 | Ubiquitination | Uniprot |
研究背景
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.
Cytoplasm. Nucleus.
Ubiquitously expressed, with high expression in heart, brain, testis and placenta.
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Belongs to the IPK1 type 2 family.
研究领域
· Environmental Information Processing > Signal transduction > Phosphatidylinositol signaling system.
· Metabolism > Carbohydrate metabolism > Inositol phosphate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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