| 产品: | SCN7A 抗体 |
| 货号: | AF9121 |
| 描述: | Rabbit polyclonal antibody to SCN7A |
| 应用: | WB |
| 反应: | Human, Mouse |
| 分子量: | 200kDa; 193kD(Calculated). |
| 蛋白号: | Q01118 |
| RRID: | AB_2843311 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF9121, RRID:AB_2843311.
展开/折叠
Putative voltage gated sodium channel subunit alpha Nax; SCN 6A; SCN 7A; SCN6A; Sodium channel protein cardiac and skeletal muscle subunit alpha; Sodium channel protein type 7 subunit alpha; Sodium channel protein type VII subunit alpha; Sodium channel voltage gated type VI alpha polypeptide; Sodium channel voltage gated type VII alpha; Sodium channel voltage gated type VII alpha polypeptide; Voltage dependent sodium channel alpha subunit;
抗原和靶标
- Q01118 SCN7A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLASPEPKGLVPFTKESFELIKQHIAKTHNEDHEEEDLKPTPDLEVGKKLPFIYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDGDRDVHATKEGAYFDKAKEKSPIQSQI
翻译修饰 - Q01118 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S58 | Phosphorylation | Uniprot | |
| Y72 | Phosphorylation | Uniprot | |
| T292 | Phosphorylation | Uniprot | |
| S387 | Phosphorylation | Uniprot | |
| Y397 | Phosphorylation | Uniprot | |
| K466 | Methylation | Uniprot | |
| T636 | Phosphorylation | Uniprot | |
| K757 | Acetylation | Uniprot | |
| T777 | Phosphorylation | Uniprot | |
| S831 | Phosphorylation | Uniprot | |
| S843 | Phosphorylation | Uniprot | |
| S905 | Phosphorylation | Uniprot | |
| S906 | Phosphorylation | Uniprot | |
| Y990 | Phosphorylation | Uniprot | |
| K1505 | Acetylation | Uniprot | |
| S1511 | Phosphorylation | Uniprot | |
| T1530 | Phosphorylation | Uniprot | |
| Y1532 | Phosphorylation | Uniprot | |
| T1619 | Phosphorylation | Uniprot | |
| T1648 | Phosphorylation | Uniprot | |
| S1649 | Phosphorylation | Uniprot |
研究背景
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 656) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4.
Cell membrane>Multi-pass membrane protein.
Heart and uterus.
The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
Belongs to the sodium channel (TC 1.A.1.10) family. SCN7A subfamily.
研究领域
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
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