| 产品: | CD171/N-CAML1 抗体 |
| 货号: | AF9123 |
| 描述: | Rabbit polyclonal antibody to CD171/N-CAML1 |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 180kDa; 140kD(Calculated). |
| 蛋白号: | P32004 |
| RRID: | AB_2843313 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF9123, RRID:AB_2843313.
展开/折叠
Antigen identified by monoclonal antibody R1; CAML1; CD171; CD171 antigen; HSAS; HSAS1; Hyd; L1; L1 cell adhesion molecule; L1-NCAM; L1cam; L1CAM_HUMAN; MASA; MIC5; N CAML1; N-CAM-L1; NCAM-L1; NCAML1; Nerve-growth factor-inducible large external glycoprotein; Neural cell adhesion molecule L1; NILE; OTTHUMP00000025992; S10; SPG1;
抗原和靶标
- P32004 L1CAM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVVALRYVWPLLLCSPCLLIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQPDTDYEIHLFKERMFRHQMAVKTNGTGRVRLPPAGFATEGWFIGFVSAIILLLLVLLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYRSLESDNEEKAFGSSQPSLNGDIKPLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGATSPINPAVALE
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P32004 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Phosphorylation | Uniprot | ||
| K56 | Ubiquitination | Uniprot | |
| K77 | Ubiquitination | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K144 | Ubiquitination | Uniprot | |
| S153 | Phosphorylation | Uniprot | |
| S163 | Phosphorylation | Uniprot | |
| K180 | Ubiquitination | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| K230 | Ubiquitination | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| K301 | Ubiquitination | Uniprot | |
| K338 | Ubiquitination | Uniprot | |
| K378 | Ubiquitination | Uniprot | |
| Y418 | Phosphorylation | Uniprot | |
| Y420 | Phosphorylation | Uniprot | |
| K515 | Ubiquitination | Uniprot | |
| T518 | Phosphorylation | Uniprot | |
| T521 | Phosphorylation | Uniprot | |
| T527 | Phosphorylation | Uniprot | |
| K530 | Acetylation | Uniprot | |
| K568 | Ubiquitination | Uniprot | |
| S611 | Phosphorylation | Uniprot | |
| K655 | Ubiquitination | Uniprot | |
| K661 | Ubiquitination | Uniprot | |
| K667 | Ubiquitination | Uniprot | |
| N671 | N-Glycosylation | Uniprot | |
| K694 | Ubiquitination | Uniprot | |
| K716 | Ubiquitination | Uniprot | |
| Y784 | Phosphorylation | Uniprot | |
| K998 | Ubiquitination | Uniprot | |
| K1150 | Ubiquitination | Uniprot | |
| Y1151 | Phosphorylation | Uniprot | |
| S1152 | Phosphorylation | Uniprot | |
| K1154 | Ubiquitination | Uniprot | |
| K1156 | Ubiquitination | Uniprot | |
| S1163 | Phosphorylation | Uniprot | |
| K1169 | Ubiquitination | Uniprot | |
| T1172 | Phosphorylation | P68400 (CSNK2A1) , P17252 (PRKCA) | Uniprot |
| Y1176 | Phosphorylation | P12931 (SRC) | Uniprot |
| S1181 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S1190 | Phosphorylation | Uniprot | |
| S1191 | Phosphorylation | Uniprot | |
| S1194 | Phosphorylation | Uniprot | |
| S1204 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| Y1211 | Phosphorylation | Uniprot | |
| Y1229 | Phosphorylation | P54753 (EPHB3) | Uniprot |
| K1235 | Ubiquitination | Uniprot | |
| S1243 | Phosphorylation | Uniprot | |
| S1244 | Phosphorylation | Uniprot | |
| T1247 | Phosphorylation | Uniprot | |
| S1248 | Phosphorylation | P28482 (MAPK1) | Uniprot |
研究背景
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.
Cell membrane>Single-pass type I membrane protein. Cell projection>Growth cone. Cell projection>Axon. Cell projection>Dendrite.
Note: Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonalne growth cones of hippocampal neurons (By similarity). In neurons, detected predominantly in axons and cell body, weak localization to dendrites (PubMed:20621658).
Interacts with SHTN1; the interaction occurs in axonal growth cones.
Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
· Organismal Systems > Development > Axon guidance. (View pathway)
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