| 产品: | NDUFS5 抗体 |
| 货号: | AF9124 |
| 描述: | Rabbit polyclonal antibody to NDUFS5 |
| 应用: | WB IHC |
| 反应: | Human, Rat |
| 预测: | Pig, Zebrafish, Rabbit |
| 分子量: | 15kDa; 13kD(Calculated). |
| 蛋白号: | O43920 |
| RRID: | AB_2843314 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF9124, RRID:AB_2843314.
展开/折叠
CI 15k; CI-15 kDa; CI15K; Complex I-15 kDa; NADH dehydrogenase (ubiquinone) Fe S protein 5, 15kDa (NADH coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 5; NADH-ubiquinone oxidoreductase 15 kDa subunit; NADH:ubiquinone oxidoreductase 15 kDa IP subunit; NDUFS5; NDUS5_HUMAN;
抗原和靶标
- O43920 NDUS5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPFLDIQKRFGLNIDRWLTIQSGEQPYKMAGRCHAFEKEWIECAHGIGYTRAEKECKIEYDDFVECLLRQKTMRRAGTIRKQRDKLIKEGKYTPPPHHIGKGEPRP
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O43920 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K8 | Ubiquitination | Uniprot | |
| K28 | Ubiquitination | Uniprot | |
| K38 | Ubiquitination | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| K91 | Sumoylation | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| K101 | Ubiquitination | Uniprot |
研究背景
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Mitochondrion inner membrane>Peripheral membrane protein. Mitochondrion intermembrane space.
Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.
Belongs to the complex I NDUFS5 subunit family.
研究领域
· Human Diseases > Endocrine and metabolic diseases > Non-alcoholic fatty liver disease (NAFLD).
· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.
· Human Diseases > Neurodegenerative diseases > Parkinson's disease.
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Metabolism > Energy metabolism > Oxidative phosphorylation.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Nervous system > Retrograde endocannabinoid signaling. (View pathway)
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