| 产品: | Rsk-4 抗体 |
| 货号: | AF9188 |
| 描述: | Rabbit polyclonal antibody to Rsk-4 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Pig, Horse, Rabbit |
| 分子量: | 84kDa; 84kD(Calculated). |
| 蛋白号: | Q9UK32 |
| RRID: | AB_2843378 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF9188, RRID:AB_2843378.
展开/折叠
90 kDa ribosomal protein S6 kinase 6; KS6A6_HUMAN; p90 RSK 6; p90-RSK 6; p90RSK6; pp90RSK4; Ribosomal protein S6 kinase 90kDa polypeptide 6; Ribosomal protein S6 kinase alpha 6; Ribosomal protein S6 kinase alpha-6; Ribosomal S6 kinase 4; rps6ka6; RSK 4; RSK-4; S6K-alpha-6;
抗原和靶标
- Q9UK32 KS6A6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLPFAPQDEPWDREMEVFSGGGASSGEVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9UK32 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S83 | Phosphorylation | Uniprot | |
| K86 | Acetylation | Uniprot | |
| K86 | Ubiquitination | Uniprot | |
| T94 | Phosphorylation | Uniprot | |
| K105 | Acetylation | Uniprot | |
| K108 | Acetylation | Uniprot | |
| Y149 | Phosphorylation | Uniprot | |
| S220 | Phosphorylation | Uniprot | |
| Y231 | Phosphorylation | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| T236 | Phosphorylation | Uniprot | |
| Y239 | Phosphorylation | Uniprot | |
| K348 | Acetylation | Uniprot | |
| K367 | Acetylation | Uniprot | |
| S372 | Phosphorylation | Uniprot | |
| S378 | Phosphorylation | Uniprot | |
| K386 | Acetylation | Uniprot | |
| S389 | Phosphorylation | Uniprot | |
| Y437 | Phosphorylation | Uniprot | |
| K441 | Ubiquitination | Uniprot | |
| Y474 | Phosphorylation | Uniprot | |
| T482 | Phosphorylation | Uniprot | |
| S521 | Phosphorylation | Uniprot | |
| Y525 | Phosphorylation | Uniprot | |
| S547 | Phosphorylation | Uniprot | |
| S555 | Phosphorylation | Uniprot | |
| K570 | Ubiquitination | Uniprot | |
| T581 | Phosphorylation | Uniprot | |
| T710 | Phosphorylation | Uniprot | |
| Y711 | Phosphorylation | Uniprot | |
| T715 | Phosphorylation | Uniprot | |
| T718 | Phosphorylation | Uniprot | |
| S730 | Phosphorylation | Uniprot | |
| S736 | Phosphorylation | Uniprot |
研究背景
Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.
Phosphorylated at Ser-232, Ser-372, and Ser-389 in serum-starved cells.
Cytoplasm>Cytosol. Nucleus.
Note: Predominantly cytosolic.
Forms a complex with MAPK3/ERK1 but not with MAPK9 or MAPK14 in serum-starved cells.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
研究领域
· Cellular Processes > Cell growth and death > Oocyte meiosis. (View pathway)
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > mTOR signaling pathway. (View pathway)
· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.
· Organismal Systems > Nervous system > Long-term potentiation.
· Organismal Systems > Nervous system > Neurotrophin signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Progesterone-mediated oocyte maturation.
限制条款
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