| 产品: | TBX2 抗体 |
| 货号: | AF9210 |
| 描述: | Rabbit polyclonal antibody to TBX2 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Horse, Rabbit, Dog |
| 分子量: | 74kDa; 75kD(Calculated). |
| 蛋白号: | Q13207 |
| RRID: | AB_2843400 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF9210, RRID:AB_2843400.
展开/折叠
FLJ10169; HGNC:11597; T box 2; T box transcription factor TBX2; T-box protein 2; T-box transcription factor TBX2; TBX2; TBX2_HUMAN;
抗原和靶标
Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.
- Q13207 TBX2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MREPALAASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALPPGALAKPLPDPGLAGAAAAAAAAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPSLRLYEEHCKPERDGAESDASSCDPPPAREPPTSPGAAPSPLRLHRARAEEKSCAADSDPEPERLSEERAGAPLGRSPAPDSASPTRLTEPERARERRSPERGKEPAESGGDGPFGLRSLEKERAEARRKDEGRKEAAEGKEQGLAPLVVQTDSASPLGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQFTMGPGAFSAMGMGHLLASVAGGGNGGGGGPGTAAGLDAGGLGPAASAASTAAPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAAAAAASALPATSAAAAAAAAAGSLSRSPFLGSARPRLRFSPYQIPVTIPPSTSLLTTGLASEGSKAAGGNSREPSPLPELALRKVGAPSRGALSPSGSAKEAANELQSIQRLVSGLESQRALSPGRESPK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q13207 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S94 | Phosphorylation | Uniprot | |
| Y165 | Phosphorylation | Uniprot | |
| K210 | Ubiquitination | Uniprot | |
| Y247 | Phosphorylation | Uniprot | |
| T252 | Phosphorylation | Uniprot | |
| Y253 | Phosphorylation | Uniprot | |
| T258 | Phosphorylation | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| K283 | Ubiquitination | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| S320 | Phosphorylation | Uniprot | |
| S323 | Phosphorylation | Uniprot | |
| S324 | Phosphorylation | Uniprot | |
| S336 | Phosphorylation | Uniprot | |
| S342 | Phosphorylation | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| S368 | Phosphorylation | Uniprot | |
| S379 | Phosphorylation | Uniprot | |
| S384 | Phosphorylation | Uniprot | |
| S386 | Phosphorylation | Uniprot | |
| T391 | Phosphorylation | Uniprot | |
| S401 | Phosphorylation | Uniprot | |
| S635 | Phosphorylation | Uniprot | |
| T638 | Phosphorylation | Uniprot | |
| S643 | Phosphorylation | Uniprot | |
| S646 | Phosphorylation | Uniprot | |
| S653 | Phosphorylation | Uniprot | |
| S657 | Phosphorylation | Uniprot | |
| S676 | Phosphorylation | Uniprot | |
| S705 | Phosphorylation | Uniprot | |
| S710 | Phosphorylation | Uniprot |
研究背景
Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation.
Nucleus.
Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.
Interacts with PML (isoform-PML-2, isoform PML-3 and isoform PML-4).
The repression domain 1 (RD1) is necessary for its interaction with PML.
限制条款
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