| 产品: | TRAF7 抗体 |
| 货号: | AF7546 |
| 描述: | Rabbit polyclonal antibody to TRAF7 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 67kD; 75kD(Calculated). |
| 蛋白号: | Q6Q0C0 |
| RRID: | AB_2843910 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF7546, RRID:AB_2843910.
展开/折叠
E3 ubiquitin protein ligase TRAF7; E3 ubiquitin-protein ligase TRAF7; RFWD1; Ring finger and WD repeat domain 1; RING finger and WD repeat-containing protein 1; RING finger protein 119; RNF119; TNF receptor associated factor 7; TNF receptor-associated factor 7; TRAF7; TRAF7_HUMAN;
抗原和靶标
Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.
- Q6Q0C0 TRAF7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSSGKSARYNRFSGGPSNLPTPDVTTGTRMETTFGPAFSAVTTITKADGTSTYKQHCRTPSSSSTLAYSPRDEEDSMPPISTPRRSDSAISVRSLHSESSMSLRSTFSLPEEEEEPEPLVFAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNVKLTVVVNNIAVAEQIGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVRCPNNPSCPPLLRMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASMLNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVWTC
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q6Q0C0 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y9 | Phosphorylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| T21 | Phosphorylation | Uniprot | |
| Y53 | Phosphorylation | Uniprot | |
| K54 | Ubiquitination | Uniprot | |
| T59 | Phosphorylation | Uniprot | |
| S61 | Phosphorylation | Uniprot | |
| S62 | Phosphorylation | Uniprot | |
| S63 | Phosphorylation | Uniprot | |
| S64 | Phosphorylation | Uniprot | |
| T65 | Phosphorylation | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| S76 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| T82 | Phosphorylation | Uniprot | |
| S86 | Phosphorylation | Uniprot | |
| S88 | Phosphorylation | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| S94 | Phosphorylation | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| S105 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| T144 | Phosphorylation | Uniprot | |
| T149 | Phosphorylation | Uniprot | |
| K160 | Ubiquitination | Uniprot | |
| S197 | Phosphorylation | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| K288 | Ubiquitination | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| K321 | Ubiquitination | Uniprot | |
| K325 | Ubiquitination | Uniprot | |
| K331 | Ubiquitination | Uniprot | |
| K346 | Ubiquitination | Uniprot | |
| K387 | Methylation | Uniprot | |
| K387 | Ubiquitination | Uniprot | |
| K430 | Ubiquitination | Uniprot | |
| K511 | Ubiquitination | Uniprot | |
| S658 | Phosphorylation | Uniprot |
研究背景
E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MAP3K3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3.
Phosphorylated by MAP3K3.
Ubiquitinates itself upon phosphorylation.
Cytoplasmic vesicle.
Note: Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.
Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.
Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme.
Belongs to the WD repeat TRAF7 family.
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