| 产品: | HPRT1 抗体 |
| 货号: | AF7567 |
| 描述: | Rabbit polyclonal antibody to HPRT1 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Dog, Chicken, Xenopus |
| 分子量: | 25kDa; 25kD(Calculated). |
| 蛋白号: | P00492 |
| RRID: | AB_2843931 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF7567, RRID:AB_2843931.
展开/折叠
HGPRT; HGPRTase; HPRT 1; HPRT_HUMAN; HPRT1; Hypoxanthine guanine phosphoribosyltransferase; Hypoxanthine phosphoribosyltransferase 1 (Lesch Nyhan syndrome); Hypoxanthine phosphoribosyltransferase 1; Hypoxanthine-guanine phosphoribosyltransferase;
抗原和靶标
- P00492 HPRT_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P00492 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S5 | Phosphorylation | Uniprot | |
| S11 | Phosphorylation | Uniprot | |
| K73 | Ubiquitination | Uniprot | |
| Y81 | Phosphorylation | Uniprot | |
| S92 | Phosphorylation | Uniprot | |
| T96 | Phosphorylation | Uniprot | |
| K103 | Methylation | Uniprot | |
| K103 | Ubiquitination | Uniprot | |
| S104 | Phosphorylation | Uniprot | |
| C106 | S-Nitrosylation | Uniprot | |
| S110 | Phosphorylation | Uniprot | |
| K115 | Acetylation | Uniprot | |
| K115 | Sumoylation | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| T124 | Phosphorylation | Uniprot | |
| T126 | Phosphorylation | Uniprot | |
| K128 | Ubiquitination | Uniprot | |
| T139 | Phosphorylation | Uniprot | |
| T142 | Phosphorylation | Uniprot | |
| T145 | Phosphorylation | Uniprot | |
| S148 | Phosphorylation | Uniprot | |
| K159 | Ubiquitination | Uniprot | |
| K166 | Ubiquitination | Uniprot | |
| K175 | Ubiquitination | Uniprot | |
| Y198 | Phosphorylation | Uniprot | |
| K213 | Ubiquitination | Uniprot |
研究背景
Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
Cytoplasm.
Homotetramer.
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
研究领域
· Metabolism > Nucleotide metabolism > Purine metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.
· Metabolism > Global and overview maps > Metabolic pathways.
限制条款
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