eIF2B epsilon Antibody - #DF10348

(2)  
产品: eIF2B epsilon 抗体
货号: DF10348
描述: Rabbit polyclonal antibody to eIF2B epsilon
应用: WB
反应: Human, Mouse, Rat
分子量: 80KD; 80kD(Calculated).
蛋白号: Q13144
RRID: AB_2844355

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Polyclonal
特异性:
eIF2B epsilon Antibody detects endogenous levels of total eIF2B epsilon.
RRID:
AB_2844355
引用格式: Affinity Biosciences Cat# DF10348, RRID:AB_2844355.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CACH; CLE; EI2BE_HUMAN; EIF 2B; eIF 2B GDP GTP exchange factor; eIF 2B GDP GTP exchange factor subunit epsilon; eIF-2B GDP-GTP exchange factor subunit epsilon; EIF2B; EIF2B5; EIF2BE; EIF2Bepsilon; Eukaryotic Translation Initiation Factor 2 Beta Epsilon; Eukaryotic translation initiation factor 2B subunit 5 epsilon 82kDa; Eukaryotic translation initiation factor 2B subunit 5 epsilon; LVWM; Translation initiation factor eIF 2B subunit epsilon; Translation initiation factor eIF-2B subunit epsilon;

抗原和靶标

免疫原:
Uniprot:

Q13144(EI2BE_HUMAN) >>Visit HPA database.

基因/基因ID:
EIF2B5(8893)
序列:
MAAPVVAPPGVVVSRANKRSGAGPGGSGGGGARGAEEEPPPPLQAVLVADSFDRRFFPISKDQPRVLLPLANVALIDYTLEFLTATGVQETFVFCCWKAAQIKEHLLKSKWCRPTSLNVVRIITSELYRSLGDVLRDVDAKALVRSDFLLVYGDVISNINITRALEEHRLRRKLEKNVSVMTMIFKESSPSHPTRCHEDNVVVAVDSTTNRVLHFQKTQGLRRFAFPLSLFQGSSDGVEVRYDLLDCHISICSPQVAQLFTDNFDYQTRDDFVRGLLVNEEILGNQIHMHVTAKEYGARVSNLHMYSAVCADVIRRWVYPLTPEANFTDSTTQSCTHSRHNIYRGPEVSLGHGSILEENVLLGSGTVIGSNCFITNSVIGPGCHIGDNVVLDQTYLWQGVRVAAGAQIHQSLLCDNAEVKERVTLKPRSVLTSQVVVGPNITLPEGSVISLHPPDAEEDEDDGEFSDDSGADQEKDKVKMKGYNPAEVGAAGKGYLWKAAGMNMEEEEELQQNLWGLKINMEEESESESEQSMDSEEPDSRGGSPQMDDIKVFQNEVLGTLQRGKEENISCDNLVLEINSLKYAYNISLKEVMQVLSHVVLEFPLQQMDSPLDSSRYCALLLPLLKAWSPVFRNYIKRAADHLEALAAIEDFFLEHEALGISMAKVLMAFYQLEILAEETILSWFSQRDTTDKGQQLRKNQQLQRFIQWLKEAEEESSEDD

翻译修饰 - Q13144 作为底物

Site PTM Type Enzyme
A2 Acetylation
S20 Phosphorylation
S27 Phosphorylation
S51 Phosphorylation P48729 (CSNK1A1)
K61 Ubiquitination
K103 Ubiquitination
K108 Ubiquitination
K141 Ubiquitination
T182 Phosphorylation
K186 Ubiquitination
K217 Ubiquitination
Y319 Phosphorylation
K420 Ubiquitination
S447 Phosphorylation
S450 Phosphorylation
S466 Phosphorylation P48729 (CSNK1A1)
S469 Phosphorylation P48729 (CSNK1A1)
K481 Ubiquitination
Y483 Phosphorylation
K493 Ubiquitination
S525 Phosphorylation
S527 Phosphorylation
S529 Phosphorylation
S532 Phosphorylation
S535 Phosphorylation P49841 (GSK3B)
S540 Phosphorylation P49841 (GSK3B) , P49840 (GSK3A)
S544 Phosphorylation P49840 (GSK3A) , P49841 (GSK3B)
K565 Ubiquitination
Y583 Phosphorylation
S610 Phosphorylation
C618 S-Nitrosylation
K693 Ubiquitination
S717 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2)
S718 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2)

研究背景

功能:

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

翻译修饰:

Phosphorylated at Ser-544 by DYRK2; this is required for subsequent phosphorylation by GSK3B (By similarity). Phosphorylated on serine and threonine residues by GSK3B; phosphorylation inhibits its function.

Polyubiquitinated, probably by NEDD4.

亚基结构:

Complex of five different subunits; alpha, beta, gamma, delta and epsilon. Interacts with RGS2.

蛋白家族:

Belongs to the eIF-2B gamma/epsilon subunits family.

研究领域

· Genetic Information Processing > Translation > RNA transport.

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